Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 7/20 | 0.59 |
| ▸ | FYN | P06241 | 2/20 | 0.44 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.43 |
| ▸ | KMO | O15229 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10355246 | 0.80 | IDO1 (0.41) | IDO1KDM4ECYP3A4MAPTNOTUM | |
| SCHEMBL7442855 | 0.80 | KDM4E (0.60) | IDO1FYNKDM4ECYP3A4MAPT | |
| SCHEMBL11004015 | 0.79 | DYRK1A (0.47) | IDO1FYNCYP3A4MAPT | |
| Hydrochloric Acid SCHEMBL10355387 | 0.79 | SMN1; SMN2 (0.41) | IDO1KDM4ECYP3A4MAPTNOTUM | |
| SCHEMBL10355617 | 0.79 | IDO1 (0.52) | IDO1HRH1KDM5BMAPT | |
| Hydrochloric Acid SCHEMBL10355391 | 0.78 | KDM4E (0.58) | IDO1FYNKDM4ECYP3A4MAPT | |
| Hydrochloric Acid SCHEMBL10355432 | 0.78 | DYRK1A (0.46) | IDO1FYNCYP3A4MAPT | |
| SCHEMBL10355322 | 0.75 | CYP11B1 (0.44) | IDO1KDM4ECYP3A4MAPT | |
| SCHEMBL28404602 | 0.71 | NUDT1 (0.51) | FYNNUDT1KMO | |
| SCHEMBL10355390 | 0.71 | CYP2A6 (0.38) | IDO1KDM4ECYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0074130-B1 | NEW IMIDAZOLE COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ZAMBON S.p.A. (IT) | 1990-09-19 | — | — | EP | disclosed |
| US-4560696-A | Analgesic, antipyretic or anti-inflammatory imidazole compounds | ZAMBON S.P.A. (IT) | 1985-12-24 | — | — | US | disclosed |
| EP-0074130-A2 | New imidazole compounds, process for the preparation thereof and pharmaceutical compositions containing them | ZAMBON S.p.A. (IT) | 1983-03-16 | — | — | EP | disclosed |