Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10355316 | 0.99 | DYRK1A (0.42) | DYRK1ACLK4PKMBRD4XDH | |
| SCHEMBL11004015 | 0.83 | DYRK1A (0.47) | DYRK1ACLK4PKMXDHCYP3A4 | |
| SCHEMBL10355401 | 0.83 | SMN1; SMN2 (0.40) | CLK4KDM4EALDH1A1IDO1ADORA3 | |
| SCHEMBL10355617 | 0.83 | IDO1 (0.52) | ALDH1A1IDO1ADORA3ADORA2ACDC7 | |
| Hydrochloric Acid SCHEMBL10355432 | 0.82 | DYRK1A (0.46) | DYRK1ACLK4PKMXDHCYP3A4 | |
| SCHEMBL10355310 | 0.82 | MAPT (0.51) | DYRK1AKDM4EALDH1A1CYP3A4IDO1 | |
| Hydrochloric Acid SCHEMBL8963870 | 0.81 | MAPT (0.47) | DYRK1ACLK4PKMXDHKDM4E | |
| Hydrochloric Acid SCHEMBL10355429 | 0.80 | MAPT (0.50) | DYRK1AKDM4EALDH1A1CYP3A4IDO1 | |
| SCHEMBL10355345 | 0.80 | CDC25A (0.42) | KDM4ECYP1A2CYP3A4IDO1 | |
| SCHEMBL10355641 | 0.80 | IDO1 (0.42) | KDM4EALDH1A1LMNAIDO1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0074130-B1 | NEW IMIDAZOLE COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ZAMBON S.p.A. (IT) | 1990-09-19 | — | — | EP | disclosed |
| US-4560696-A | Analgesic, antipyretic or anti-inflammatory imidazole compounds | ZAMBON S.P.A. (IT) | 1985-12-24 | — | — | US | disclosed |
| EP-0074130-A2 | New imidazole compounds, process for the preparation thereof and pharmaceutical compositions containing them | ZAMBON S.p.A. (IT) | 1983-03-16 | — | — | EP | disclosed |