Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.39 |
| ▸ | CDK1 | P06493 | 3/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.39 |
| ▸ | GSK3A | P49840 | 3/20 | 0.39 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10355430 | 0.85 | MAPK14 (0.35) | SMN1; SMN2MAPTADORA3KDM4EHTT | |
| SCHEMBL10355350 | 0.84 | P2RX7 (0.38) | SMN1; SMN2KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL10355409 | 0.83 | DYRK1A (0.43) | ALDH1A1CCNB2CDK1CCNB1GSK3A | |
| SCHEMBL10355310 | 0.83 | MAPT (0.51) | SMN1; SMN2KMT2AMEN1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL10355316 | 0.82 | DYRK1A (0.42) | ALDH1A1CCNB2CDK1CCNB1GSK3A | |
| Hydrochloric Acid SCHEMBL10355359 | 0.82 | SMN1; SMN2 (0.40) | SMN1; SMN2KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL11002021 | 0.82 | ADORA3 (0.34) | SMN1; SMN2ALDH1A1MAPTADORA3KDM4E | |
| Hydrochloric Acid SCHEMBL10355429 | 0.82 | MAPT (0.50) | SMN1; SMN2KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL10355641 | 0.82 | IDO1 (0.42) | SMN1; SMN2KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL10355625 | 0.82 | IDO1 (0.32) | MAPTKDM4EIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0074130-B1 | NEW IMIDAZOLE COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ZAMBON S.p.A. (IT) | 1990-09-19 | — | — | EP | disclosed |
| US-4560696-A | Analgesic, antipyretic or anti-inflammatory imidazole compounds | ZAMBON S.P.A. (IT) | 1985-12-24 | — | — | US | disclosed |
| EP-0074130-A2 | New imidazole compounds, process for the preparation thereof and pharmaceutical compositions containing them | ZAMBON S.p.A. (IT) | 1983-03-16 | — | — | EP | disclosed |