Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.63 |
| ▸ | RAB9A | P51151 | 3/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10356535 | 0.87 | NPC1 (0.50) | POLBRAB9ANPC1TDP1KMT2A | |
| SCHEMBL10356624 | 0.86 | KDR (0.49) | POLBRAB9ANPC1TDP1KMT2A | |
| SCHEMBL10356574 | 0.85 | KDR (0.48) | POLBRAB9ANPC1TDP1KMT2A | |
| SCHEMBL3365882 | 0.85 | ALDH1A1 (0.72) | POLBRAB9ANPC1TDP1KMT2A | |
| SCHEMBL10356536 | 0.84 | MAPT (0.51) | POLBRAB9ANPC1TDP1MAPK1 | |
| SCHEMBL10356619 | 0.84 | KDR (0.50) | POLBRAB9ANPC1TDP1SMN1; SMN2 | |
| SCHEMBL9522611 | 0.83 | S1PR4 (0.51) | POLBRAB9ANPC1KMT2AMEN1 | |
| SCHEMBL10357487 | 0.83 | CACNA1B (0.65) | POLBRAB9ANPC1TDP1KMT2A | |
| SCHEMBL10356262 | 0.82 | HDAC6 (0.52) | POLBTDP1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL10567645 | 0.82 | MAPT (0.66) | POLBRAB9AKMT2AMEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0213924-B1 | P-ACYLAMINOBENZAMIDES | ELI LILLY AND COMPANY (US) | 1990-10-17 | — | — | EP | disclosed |
| EP-0213924-A2 | p-Acylaminobenzamides | ELI LILLY AND COMPANY (US) | 1987-03-11 | — | — | EP | disclosed |
| US-4642379-A | 4-ACYLAMINO BENZAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1987-02-10 | — | — | US | disclosed |