Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 14/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 14/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 12/20 | 1.00 |
| ▸ | MAPT | P10636 | 10/20 | 1.00 |
| ▸ | HPGD | P15428 | 10/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 5/20 | 1.00 |
| ▸ | NFKB2 | Q00653 | 5/20 | 1.00 |
| ▸ | RELA | Q04206 | 5/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 3/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 1.00 |
| ▸ | RAB9A | P51151 | 7/20 | 0.76 |
| ▸ | NPC1 | O15118 | 6/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.76 |
| ▸ | TP53 | P04637 | 4/20 | 0.76 |
| ▸ | USP2 | O75604 | 3/20 | 0.76 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17938574 | 0.88 | MEN1 (0.78) | MEN1KMT2AALOX15MAPTHPGD | |
| SCHEMBL403449 | 0.87 | KMT2A (1.00) | MEN1KMT2AALOX15MAPTHPGD | |
| SCHEMBL10357394 | 0.86 | MAPT (0.82) | MEN1KMT2AALOX15MAPTHPGD | |
| SCHEMBL22415570 | 0.86 | MAPT (0.76) | MEN1KMT2AALOX15MAPTHPGD | |
| SCHEMBL10357372 | 0.83 | MAPT (0.90) | MEN1KMT2AALOX15MAPTHPGD | |
| SCHEMBL10357437 | 0.82 | KMT2A (1.00) | MEN1KMT2AALOX15MAPTHPGD | |
| SCHEMBL10357362 | 0.81 | KMT2A (0.78) | MEN1KMT2AALOX15MAPTHPGD | |
| SCHEMBL10357589 | 0.81 | SMN1; SMN2 (1.00) | MEN1KMT2AALOX15MAPTHPGD | |
| SCHEMBL16841251 | 0.81 | MEN1 (0.74) | MEN1KMT2AALOX15MAPTHPGD | |
| SCHEMBL10358211 | 0.81 | MAPT (0.68) | MEN1KMT2AALOX15MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120184583-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-07-19 | — | — | US | disclosed |
| US-20120184583-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-07-19 | — | — | US | disclosed |
| US-20100144798-A1 | Modulators of ATP-Binding Cassette Transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-06-10 | — | — | US | disclosed |
| US-20100144798-A1 | Modulators of ATP-Binding Cassette Transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184583-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | MEN1 4723/4885KMT2A 4334/4885ALOX15 3215/4885 |
| US-20100144798-A1 | Modulators of ATP-Binding Cassette Transporters | CFTR, ABCB1, ABCC2 | MEN1 4723/4885KMT2A 4334/4885ALOX15 3215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.