ABCC2

ATP-binding cassette sub-family C member 2 · Q92887 · ABCC2 on Sugi Atlas →

55,165 patent compounds predicted against ABCC2, 44,834 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Rifaximin (SCHEMBL124066)	1.00	4/20
Rifaximin (SCHEMBL124067)	1.00	4/20
Rifaximin (SCHEMBL140435)	1.00	4/20
Rifaximin (SCHEMBL182279)	1.00	4/20
Rifamycin (SCHEMBL2320)	0.70	4/20
Rifamycin (SCHEMBL151824)	0.70	4/20
Rifamycin (SCHEMBL182452)	0.70	4/20
Rifamexil (SCHEMBL191882)	0.70	4/20
Rifamide (SCHEMBL49236)	0.63	4/20
Rifamide (SCHEMBL49237)	0.63	4/20
Verlukast (SCHEMBL37246)	1.00	3/20
Verlukast (SCHEMBL37247)	1.00	3/20
Rifapentine (SCHEMBL41590)	1.00	3/20
Rifapentine (SCHEMBL41591)	1.00	3/20
Verlukast (SCHEMBL156453)	1.00	3/20
Mk-571 (SCHEMBL156452)	0.98	3/20
Verlukast (SCHEMBL156454)	0.98	3/20
Rifametane (SCHEMBL192716)	0.77	3/20
Rifabutin (SCHEMBL173466)	0.70	3/20
Rifabutin (SCHEMBL154848)	0.69	3/20

Clinical trials — most relevant to ABCC2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Digoxin Dosing in Heart Failure: A Simplified Nomogram Versus Standard Care	PHASE4	COMPLETED
Paclitaxel, Nab-paclitaxel, or Ixabepilone With or Without Bevacizumab in Treating Patients With Stage IIIC or Stage IV Breast Cancer	PHASE3	COMPLETED
Cardioprotective Empagliflozin for Cancer Patients Receiving Doxorubicin	PHASE2/PHASE3	UNKNOWN
Study of the Long-term Effects of P2Y12 Inhibitor Monotherapy and Coagulation Markers After Percutaneous Coronary Angioplasty.	PHASE3	RECRUITING
A Phase 2 Trial of SCO-101 in Combination With FOLFIRI for Patients With Metastatic Colorectal Cancer (mCRC) With Acquired Resistance to FOLFIRI	PHASE1/PHASE2	UNKNOWN
Clofarabine and Cytarabine in Treating Young Patients With Refractory or Relapsed Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia	PHASE1/PHASE2	COMPLETED
The Evaluation of the Drug R3R01 for the Excretion of Protein in the Urine in Patients With Diabetic Kidney Disease.	PHASE2	RECRUITING
CELECOXIB Plasma and Cerebral Spinal Fluid Pharmacokinetics in Children	PHASE2	RECRUITING
Surgery Plus Chemotherapy (Doxorubicin, Vincristine and Etoposide), Mitotane, and Tariquidar to Treat Adrenocortical Cancer	PHASE2	COMPLETED
A Study of ABC294640 Alone and in Combination With HCQ Sulfate in the Treatment of Advanced Cholangiocarcinoma	PHASE2	COMPLETED
Influence of Ethnicity and ABCB1 Gene Polymorphism on the Pharmacokinetics of Azithromycin in Healthy Bangladeshi Volunteers	PHASE1	UNKNOWN
Indenoisoquinoline LMP744 in Adults With Relapsed Solid Tumors and Lymphomas	PHASE1	COMPLETED
PK Study of Oral and IV Clofarabine in High Risk Myelodysplasia+Acute Leukemias	PHASE1	COMPLETED
the Effect of ABCC2 Genetic Polymorphism on Neurotoxicity in Gastrointestinal Cancer Patients Receiving Oxaliplatin	nan	UNKNOWN
Multidrug Resistance Genes in Patients With Acute Myeloid Leukemia	nan	ACTIVE_NOT_RECRUITING
Study of ABCB1,SLC22A16 Drug Transporter Genes and Doxorubicin and Cyclophosphamide Toxicity in Brest Cancer Patient	nan	UNKNOWN
Coproporphyrine Isomers and Methotrexate Elimination	nan	COMPLETED
Bile Acids Metabolism and Genetic Mutation Profile in the Intrahepatic Cholestasis of Pregnacy in Indian Population	nan	RECRUITING
Studying DNA in Tissue Samples From Caucasian and African-American Cancer Patients Who Received Docetaxel on Clinical Trial CLB-9871	nan	COMPLETED
Pharmacogenetics Study in Taiwan's Ethnic Groups	nan	COMPLETED
Collection of Tissue Samples for Study of Multidrug Resistance	nan	COMPLETED
Cancer and Hearing Loss Related in Children	nan	COMPLETED
Placental Transfer of Tenofovir	nan	COMPLETED
Impact of Genetics on Metformin Pharmacokinetics	nan	COMPLETED
Pharmacogenomics of New Antiretrovirals	nan	COMPLETED
Metformin Reduce the Relapse Rate on Patients With B-cell Precursor (Ph+ Negative) Acute Lymphoblastic Leukemia	nan	COMPLETED
Clinical Features and Potential Etiology of Epilepsy and Nodding Syndrome in the Mahenge Area, Ulanga District	nan	UNKNOWN
Role of the ATP7A Transporter in Ovarian Cancer	nan	COMPLETED
Effect of Metformin on ABCB1 and AMPK Expression in Adolescents With Newly Diagnosed Acute Lymphoblastic Leukemia	nan	UNKNOWN
Evaluation of Primex's PGX Assay to Assess the Clinical Utility of Pharmacogenomics	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a ABCC2 binder may also engage these)

Protein	Name	Similarity
Q63120	—	1.000	Q63120 →
Q8VI47	—	1.000	Q8VI47 →
Q28689	—	0.998	Q28689 →
Q09429	—	0.996	Q09429 →
ABCC8	ATP-binding cassette sub-family C member 8	0.995	landscape →
Q9C8G9	—	0.995	Q9C8G9 →
P39109	—	0.994	P39109 →
Q63563	—	0.994	Q63563 →
Q9U2G5	—	0.994	Q9U2G5 →
Q9M1C7	—	0.994	Q9M1C7 →
Q09YH0	—	0.994	Q09YH0 →
Q09427	—	0.994	Q09427 →
Q7JII8	—	0.993	Q7JII8 →
Q9TUQ2	—	0.993	Q9TUQ2 →
Q9R1X5	—	0.993	Q9R1X5 →
Q2QLH0	—	0.993	Q2QLH0 →
Q07E16	—	0.992	Q07E16 →
Q9QYM0	—	0.992	Q9QYM0 →
Q00554	—	0.992	Q00554 →
Q96J66	—	0.992	Q96J66 →
O35379	—	0.992	O35379 →
P26361	—	0.992	P26361 →
P91660	—	0.992	P91660 →
P82451	—	0.992	P82451 →
Q2QLB4	—	0.992	Q2QLB4 →
Q09YK5	—	0.991	Q09YK5 →
Q00555	—	0.991	Q00555 →
Q00PJ2	—	0.991	Q00PJ2 →
P35071	—	0.991	P35071 →
Q2QLE5	—	0.991	Q2QLE5 →