Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 10/20 | 0.55 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10358558 | 0.88 | BRD4 (0.46) | BRD4PARP1MAOBCREBBPKMT2A | |
| SCHEMBL3293755 | 0.83 | BRD4 (0.60) | BRD4PARP1CREBBPKMT2ALMNA | |
| SCHEMBL24508622 | 0.82 | BRD4 (0.55) | BRD4PARP1CREBBPKMT2ALMNA | |
| SCHEMBL4969061 | 0.82 | BRD4 (0.55) | BRD4PARP1CREBBPKMT2ALMNA | |
| SCHEMBL17027131 | 0.81 | BRD4 (0.52) | BRD4PARP1CREBBPKMT2AMEN1 | |
| SCHEMBL7468490 | 0.81 | BRD4 (0.42) | BRD4PARP1MAOBCREBBPPDE3B | |
| SCHEMBL4824516 | 0.80 | PARP1 (0.60) | BRD4PARP1CREBBPKMT2APDE3B | |
| SCHEMBL10359124 | 0.79 | BRD4 (0.53) | BRD4MAOBCREBBPKMT2AMEN1 | |
| SCHEMBL23775580 | 0.79 | BRD4 (0.53) | BRD4PARP1CREBBPKMT2ALMNA | |
| SCHEMBL4971157 | 0.78 | KMT2A (0.53) | BRD4KMT2AMEN1ALDH1A1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0243018-B1 | THIOLACTAM-N-ACETIC ACID DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1990-10-24 | — | — | EP | disclosed |
| US-4771050-A | ALDOSE REDUCTASE INHIBITOR, ANTICOAGULANTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1988-09-13 | — | — | US | disclosed |
| EP-0243018-A1 | Thiolactam-N-acetic acid derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1987-10-28 | — | — | EP | disclosed |