Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 7/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10359034 | 0.89 | BRD4 (0.44) | BRD4CA2ALDH1A1KMT2AMEN1 | |
| SCHEMBL3293755 | 0.81 | BRD4 (0.60) | BRD4CREBBPALDH1A1KMT2AMEN1 | |
| SCHEMBL13870348 | 0.81 | PARP1 (0.57) | BRD4CA2CREBBPALDH1A1KMT2A | |
| SCHEMBL10358498 | 0.79 | BRD4 (0.55) | BRD4CREBBPALDH1A1KMT2AMEN1 | |
| SCHEMBL4969061 | 0.79 | BRD4 (0.55) | BRD4CREBBPALDH1A1KMT2AMEN1 | |
| SCHEMBL24508622 | 0.79 | BRD4 (0.55) | BRD4CREBBPALDH1A1KMT2AMEN1 | |
| SCHEMBL914279 | 0.79 | CA2 (0.46) | BRD4CA2CREBBPALDH1A1KMT2A | |
| SCHEMBL13135833 | 0.79 | CA2 (0.46) | BRD4CA2CREBBPALDH1A1KMT2A | |
| SCHEMBL30060716 | 0.79 | CA2 (0.46) | BRD4CA2CREBBPALDH1A1KMT2A | |
| SCHEMBL23775580 | 0.77 | BRD4 (0.53) | BRD4CREBBPALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0243018-B1 | THIOLACTAM-N-ACETIC ACID DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1990-10-24 | — | — | EP | disclosed |
| US-4771050-A | ALDOSE REDUCTASE INHIBITOR, ANTICOAGULANTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1988-09-13 | — | — | US | disclosed |
| EP-0243018-A1 | Thiolactam-N-acetic acid derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1987-10-28 | — | — | EP | disclosed |