Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | PTGDR2 | Q9Y5Y4 | 9/20 | 0.49 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | AGER | Q15109 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | CDC25B | P30305 | 1/20 | 0.36 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbamic Acid SCHEMBL10358551 | 0.93 | PTGDR2 (0.52) | HTTPTGDR2RXRAMAPK1NPSR1 | |
| SCHEMBL10359072 | 0.87 | PTGDR2 (0.47) | HTTPTGDR2RXRAMAPK1NPSR1 | |
| SCHEMBL11869027 | 0.83 | PTGDR2 (0.47) | HTTPTGDR2RXRAMAPK1NPSR1 | |
| SCHEMBL11857643 | 0.83 | PTGDR2 (0.72) | PTGDR2ALDH1A1KDM4ECYP1A2CYP2C9 | |
| SCHEMBL10358552 | 0.82 | PTGDR2 (0.47) | HTTPTGDR2RXRAMAPK1NPSR1 | |
| SCHEMBL10359069 | 0.81 | PTGDR2 (0.44) | HTTPTGDR2RXRAMAPK1NPSR1 | |
| SCHEMBL10359071 | 0.78 | PTGDR2 (0.43) | HTTPTGDR2RXRAMAPK1NPSR1 | |
| SCHEMBL10358535 | 0.77 | HTT (0.73) | HTTPTGDR2MAPK1ALDH1A1KDM4E | |
| SCHEMBL10358559 | 0.76 | MYC (0.51) | HTTPTGDR2ALDH1A1KDM4EGAA | |
| SCHEMBL1363296 | 0.74 | HTT (0.49) | HTTPTGDR2AGERALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0267986-B1 | \"(2-AMINO-4-ARYL-THIAZOLE-5-YL)ETHANOLS AND THEIR DERIVATIVES HAVING DIURETIC ACTIVITY AND METHODS FOR PREPARING THE SAME | ISTITUTO LUSO FARMACO D'ITALIA S.p.A. (IT) | 1990-11-22 | — | — | EP | claimed |
| EP-0267986-B1 | \"(2-AMINO-4-ARYL-THIAZOLE-5-YL)ETHANOLS AND THEIR DERIVATIVES HAVING DIURETIC ACTIVITY AND METHODS FOR PREPARING THE SAME | ISTITUTO LUSO FARMACO D'ITALIA S.p.A. (IT) | 1990-11-22 | — | — | EP | disclosed |
| US-4761422-A | (2-amino-4-aryl-thiazole-5-yl)ethanols and their derivatives having diuretic activity and methods for preparing the same | LUSOFARMACO ISTITUTO LUSOFARMACO D'ITALIA SPA (IT) | 1988-08-02 | — | — | US | disclosed |
| EP-0267986-A1 | \"(2-amino-4-aryl-thiazole-5-yl)ethanols and their derivatives having diuretic activity and methods for preparing the same | ISTITUTO LUSO FARMACO D'ITALIA S.p.A. (IT) | 1988-05-25 | — | — | EP | disclosed |