Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 10/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | AGER | Q15109 | 6/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11869027 | 0.90 | PTGDR2 (0.47) | PTGDR2HTTRXRAMAPK1NPSR1 | |
| SCHEMBL10359071 | 0.89 | PTGDR2 (0.43) | PTGDR2HTTRXRAMAPK1NPSR1 | |
| Carbamic Acid SCHEMBL10358551 | 0.85 | PTGDR2 (0.52) | PTGDR2HTTRXRAMAPK1NPSR1 | |
| SCHEMBL10358564 | 0.82 | HTT (0.51) | PTGDR2HTTRXRAMAPK1NPSR1 | |
| SCHEMBL10358652 | 0.81 | HTT (0.61) | PTGDR2HTTALDH1A1KDM4ECYP1A2 | |
| SCHEMBL10359072 | 0.80 | PTGDR2 (0.47) | PTGDR2HTTRXRAMAPK1NPSR1 | |
| SCHEMBL10359035 | 0.80 | PTGDR2 (0.48) | PTGDR2HTTAGERDHODHALDH1A1 | |
| SCHEMBL11857643 | 0.79 | PTGDR2 (0.72) | PTGDR2ALDH1A1KDM4ECYP1A2CYP2C9 | |
| SCHEMBL10359069 | 0.72 | PTGDR2 (0.44) | PTGDR2HTTRXRAMAPK1NPSR1 | |
| SCHEMBL10358690 | 0.70 | HTT (0.55) | PTGDR2HTTALDH1A1KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0267986-B1 | \"(2-AMINO-4-ARYL-THIAZOLE-5-YL)ETHANOLS AND THEIR DERIVATIVES HAVING DIURETIC ACTIVITY AND METHODS FOR PREPARING THE SAME | ISTITUTO LUSO FARMACO D'ITALIA S.p.A. (IT) | 1990-11-22 | — | — | EP | claimed |
| US-4761422-A | (2-amino-4-aryl-thiazole-5-yl)ethanols and their derivatives having diuretic activity and methods for preparing the same | LUSOFARMACO ISTITUTO LUSOFARMACO D'ITALIA SPA (IT) | 1988-08-02 | — | — | US | claimed |
| EP-0267986-B1 | \"(2-AMINO-4-ARYL-THIAZOLE-5-YL)ETHANOLS AND THEIR DERIVATIVES HAVING DIURETIC ACTIVITY AND METHODS FOR PREPARING THE SAME | ISTITUTO LUSO FARMACO D'ITALIA S.p.A. (IT) | 1990-11-22 | — | — | EP | disclosed |
| US-4761422-A | (2-amino-4-aryl-thiazole-5-yl)ethanols and their derivatives having diuretic activity and methods for preparing the same | LUSOFARMACO ISTITUTO LUSOFARMACO D'ITALIA SPA (IT) | 1988-08-02 | — | — | US | disclosed |
| EP-0267986-A1 | \"(2-amino-4-aryl-thiazole-5-yl)ethanols and their derivatives having diuretic activity and methods for preparing the same | ISTITUTO LUSO FARMACO D'ITALIA S.p.A. (IT) | 1988-05-25 | — | — | EP | disclosed |