Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 16/20 | 0.72 |
| ▸ | GAA | P10253 | 4/20 | 0.72 |
| ▸ | MAPT | P10636 | 4/20 | 0.72 |
| ▸ | MEN1 | O00255 | 4/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.72 |
| ▸ | POLB | P06746 | 2/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | DHODH | Q02127 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11852874 | 0.84 | PTGDR2 (1.00) | PTGDR2GAAMAPTMEN1KMT2A | |
| SCHEMBL14433253 | 0.82 | PTGDR2 (0.65) | PTGDR2GAAMAPTMEN1KMT2A | |
| SCHEMBL10358559 | 0.81 | MYC (0.51) | PTGDR2GAAMAPTMEN1KMT2A | |
| Carbamic Acid SCHEMBL10359033 | 0.80 | PTGDR2 (0.53) | PTGDR2GAAMAPTMEN1KMT2A | |
| SCHEMBL29044444 | 0.75 | GAA (0.59) | PTGDR2GAAMAPTMEN1KMT2A | |
| SCHEMBL1884723 | 0.75 | PTGDR2 (0.61) | PTGDR2GAAMAPTMEN1KMT2A | |
| Carbamic Acid SCHEMBL10358650 | 0.74 | HTT (0.64) | PTGDR2GAAMAPTMEN1KMT2A | |
| SCHEMBL10358535 | 0.74 | HTT (0.73) | PTGDR2GAAMAPTMEN1KMT2A | |
| SCHEMBL28250062 | 0.74 | PTGDR2 (0.68) | PTGDR2GAAMAPTMEN1KMT2A | |
| SCHEMBL28925053 | 0.73 | PTGDR2 (0.65) | PTGDR2GAAMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0267986-B1 | \"(2-AMINO-4-ARYL-THIAZOLE-5-YL)ETHANOLS AND THEIR DERIVATIVES HAVING DIURETIC ACTIVITY AND METHODS FOR PREPARING THE SAME | ISTITUTO LUSO FARMACO D'ITALIA S.p.A. (IT) | 1990-11-22 | — | — | EP | disclosed |
| US-4761422-A | (2-amino-4-aryl-thiazole-5-yl)ethanols and their derivatives having diuretic activity and methods for preparing the same | LUSOFARMACO ISTITUTO LUSOFARMACO D'ITALIA SPA (IT) | 1988-08-02 | — | — | US | disclosed |
| EP-0267986-A1 | \"(2-amino-4-aryl-thiazole-5-yl)ethanols and their derivatives having diuretic activity and methods for preparing the same | ISTITUTO LUSO FARMACO D'ITALIA S.p.A. (IT) | 1988-05-25 | — | — | EP | disclosed |