Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | EP300 | Q09472 | 1/20 | 0.32 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.32 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1036073 | 1.00 | AXL (0.46) | AXLCCNT1CDK9HASPINCCNC | |
| SCHEMBL1034122 | 0.77 | AXL (0.50) | AXLCCNT1CDK9HASPINCCNC | |
| SCHEMBL29566353 | 0.77 | AXL (0.50) | AXLCCNT1CDK9HASPINCCNC | |
| SCHEMBL2516694 | 0.77 | HPGD (0.46) | KDM4ENPC1RAB9AL3MBTL1PLAU | |
| SCHEMBL13249042 | 0.77 | HPGD (0.46) | KDM4ENPC1RAB9AL3MBTL1PLAU | |
| SCHEMBL4764881 | 0.77 | CCNC (0.50) | AXLCCNT1CDK9HASPINCCNC | |
| SCHEMBL4764878 | 0.77 | CCNC (0.50) | AXLCCNT1CDK9HASPINCCNC | |
| SCHEMBL2516696 | 0.77 | HPGD (0.46) | KDM4ENPC1RAB9AL3MBTL1PLAU | |
| SCHEMBL13213072 | 0.77 | CCNT1 (0.42) | AXLCCNT1CDK9HASPINCCNC | |
| SCHEMBL15716494 | 0.77 | CCNC (0.50) | AXLCCNT1CDK9HASPINCCNC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871941-B2 | 8-bromo-5-quinolinecarboxaldehyde oxime | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2014-10-28 | — | — | US | disclosed |
| US-20140249314-A1 | ISOXAZOLINES FOR CONTROLLING INVERTEBRATE PESTS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2014-09-04 | — | — | US | disclosed |
| US-20140038821-A1 | ISOXAZOLINES FOR CONTROLLING INVERTEBRATE PESTS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2014-02-06 | — | — | US | disclosed |
| US-8552218-B2 | Isoxazolines for controlling invertebrate pests | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2013-10-08 | — | — | US | disclosed |
| US-20130029845-A1 | ISOXAZOLINES FOR CONTROLLING INVERTEBRATE PESTS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2013-01-31 | — | — | US | disclosed |
| US-8231888-B2 | Isoxazolines for controlling invertebrate pests | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-07-31 | — | — | US | disclosed |
| US-20110263641-A1 | Isoxazolines For Controlling Invertebrate Pests | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2011-10-27 | — | — | US | disclosed |
| US-7964204-B2 | Isoxazolines for controlling invertebrate pests | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2011-06-21 | — | — | US | disclosed |
| EP-1973888-B1 | ISOXAZOLINES FOR CONTROLLING INVERTEBRATE PESTS | DU PONT (US) | 2011-01-26 | — | — | EP | disclosed |
| US-20100234219-A1 | Isoxazolines for Controlling Invertebrate Pests | CORTEVA AGRISCIENCE LLC | 2010-09-16 | — | — | US | disclosed |
| EP-1973888-A1 | ISOXAZOLINES FOR CONTROLLING INVERTEBRATE PESTS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007079162-A1 | ISOXAZOLINES FOR CONTROLLING INVERTEBRATE PESTS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2007-07-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140249314-A1 | ISOXAZOLINES FOR CONTROLLING INVERTEBRATE PESTS | C1S, C3AR1, CBR3 | AXL 1045/4885CCNT1 630/4885CDK9 3295/4885 |
| US-20130029845-A1 | ISOXAZOLINES FOR CONTROLLING INVERTEBRATE PESTS | C1S, C3AR1, CBR3 | AXL 1045/4885CCNT1 630/4885CDK9 3295/4885 |
| US-20100234219-A1 | Isoxazolines for Controlling Invertebrate Pests | C1S, C3AR1, CBR3 | AXL 1269/4885CCNT1 416/4885CDK9 3180/4885 |
| US-20140038821-A1 | ISOXAZOLINES FOR CONTROLLING INVERTEBRATE PESTS | C1S, C3AR1, CBR3 | AXL 1045/4885CCNT1 630/4885CDK9 3295/4885 |
| US-20110263641-A1 | Isoxazolines For Controlling Invertebrate Pests | C1S, C3AR1, CBR3 | AXL 817/4885CCNT1 693/4885CDK9 3443/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.