Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.53 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.53 |
| ▸ | CCNK | O75909 | 3/20 | 0.44 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.44 |
| ▸ | CCR6 | P51684 | 6/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 4/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1036089 | 1.00 | CYP3A4 (0.53) | CYP3A4CYP2D6CYP2C9HSD11B1HSD11B2 | |
| SCHEMBL23292267 | 0.88 | CYP3A4 (0.55) | CYP3A4CYP2D6CYP2C9HSD11B1HSD11B2 | |
| SCHEMBL1771092 | 0.85 | CYP3A4 (0.55) | CYP3A4CYP2D6CYP2C9HSD11B1HSD11B2 | |
| SCHEMBL12596718 | 0.85 | CYP3A4 (0.55) | CYP3A4CYP2D6CYP2C9HSD11B1HSD11B2 | |
| SCHEMBL1771089 | 0.85 | CYP3A4 (0.55) | CYP3A4CYP2D6CYP2C9HSD11B1HSD11B2 | |
| SCHEMBL1771088 | 0.85 | CYP3A4 (0.55) | CYP3A4CYP2D6CYP2C9HSD11B1HSD11B2 | |
| SCHEMBL1771811 | 0.85 | CYP3A4 (0.63) | CYP3A4CYP2D6CYP2C9HSD11B1HSD11B2 | |
| SCHEMBL1771813 | 0.85 | CYP3A4 (0.63) | CYP3A4CYP2D6CYP2C9HSD11B1HSD11B2 | |
| SCHEMBL12596717 | 0.85 | CYP3A4 (0.63) | CYP3A4CYP2D6CYP2C9HSD11B1HSD11B2 | |
| SCHEMBL1771809 | 0.85 | CYP3A4 (0.63) | CYP3A4CYP2D6CYP2C9HSD11B1HSD11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276730-A2 | CARBAMATE AND UREA INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | Vitae Pharmaceuticals, Inc. (US) | 2011-01-26 | — | — | EP | disclosed |
| WO-2009131669-A2 | CARBAMATE AND UREA INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | disclosed |