Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 11/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10360821 | 0.88 | MAOB (0.49) | MAOBCYP19A1NR3C2AKR1B1PARP1 | |
| SCHEMBL130268 | 0.82 | CYP19A1 (0.49) | MAOBCYP19A1ALDH1A1 | |
| SCHEMBL6703209 | 0.82 | CYP19A1 (0.42) | CYP19A1CA2ALDH1A1 | |
| SCHEMBL13730471 | 0.82 | CYP19A1 (0.49) | MAOBCYP19A1ALDH1A1 | |
| SCHEMBL2474551 | 0.82 | MAOB (0.49) | MAOBCYP19A1 | |
| SCHEMBL10426192 | 0.81 | CYP19A1 (0.46) | MAOBCYP19A1NR3C2ALDH1A1 | |
| SCHEMBL19746 | 0.81 | CYP19A1 (0.45) | MAOBCYP19A1CA2ALDH1A1 | |
| SCHEMBL11733122 | 0.80 | CYP19A1 (0.44) | MAOBCYP19A1CA2ALDH1A1 | |
| Methane SCHEMBL27973705 | 0.80 | CYP19A1 (0.44) | MAOBCYP19A1CA2ALDH1A1 | |
| SCHEMBL131516 | 0.79 | CYP19A1 (0.52) | MAOBCYP19A1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0139614-B1 | PHARMACEUTICAL PREPARATIONS CONTAINING FLAVANONE OR THIOFLAVANONE DERIVATIVES, THE USE THEREOF, NOVEL FLAVANONES AND THIOFLAVANONES, AND PROCESSES FOR THEIR MANUFACTURE | Zyma SA (CH) | 1990-08-22 | — | — | EP | disclosed |
| US-4935441-A | Flavene and thioflavene derivates, processes for their manufacture, pharmaceutical preparations that contain such compounds, and the use of the latter | ZYMA SA (CH) | 1990-06-19 | — | — | US | disclosed |
| US-4885298-A | Pharmaceutical preparations containing flavanone or thioflavanone derivatives the use thereof, novel flavanones and thioflavanones, and processes for their manufacture | ZYMA SA (CH) | 1989-12-05 | — | — | US | disclosed |
| EP-0139615-B1 | FLAVENE AND THIOFLAVENE DERIVATIVES, PROCESSES FOR THEIR MANUFACTURE, PHARMACEUTICAL PREPARATIONS THAT CONTAIN SUCH COMPOUNDS, AND THE USE OF THE LATTER | Zyma SA (CH) | 1989-04-19 | — | — | EP | disclosed |
| EP-0139615-A2 | Flavene and thioflavene derivatives, processes for their manufacture, pharmaceutical preparations that contain such compounds, and the use of the latter | Zyma SA (CH) | 1985-05-02 | — | — | EP | disclosed |
| EP-0139614-A2 | Pharmaceutical preparations containing flavanone or thioflavanone derivatives, the use thereof, novel flavanones and thioflavanones, and processes for their manufacture | Zyma SA (CH) | 1985-05-02 | — | — | EP | disclosed |