SCHEMBL130268

SCHEMBL130268

O=C1Cc2ccc(O)cc2OC1c1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 5/20 0.49
MAOA P21397 1/20 0.49
MAOB P27338 1/20 0.49
PSMB5 P28074 1/20 0.49
ESR2 Q92731 3/20 0.48
ESR1 P03372 2/20 0.48
AR P10275 1/20 0.46
HSD17B10 Q99714 3/20 0.42
ALDH1A1 P00352 2/20 0.42
GAA P10253 1/20 0.42
HPGD P15428 1/20 0.42
CYP3A4 P08684 2/20 0.41
MAPT P10636 2/20 0.41
CYP1A1 P04798 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP1B1 Q16678 1/20 0.41
KDM4E B2RXH2 1/20 0.41
ALOX15 P16050 1/20 0.41
MAPK1 P28482 1/20 0.41
MEN1 O00255 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13730471 1.00 CYP19A1 (0.49) CYP19A1MAOAMAOBPSMB5ESR2
SCHEMBL1071070 0.91 ESR2 (0.51) CYP19A1MAOAMAOBPSMB5ESR2
SCHEMBL126600 0.88 AR (0.52) CYP19A1MAOAMAOBPSMB5ESR2
SCHEMBL3696621 0.83 KDM4E (0.54) CYP19A1PSMB5ESR2ESR1HSD17B10
SCHEMBL28625919 0.82 HSD17B1 (0.46) CYP19A1ESR2ESR1HSD17B10ALDH1A1
SCHEMBL10360964 0.82 MAOB (0.49) CYP19A1MAOBALDH1A1
SCHEMBL6703209 0.82 CYP19A1 (0.42) CYP19A1ARALDH1A1CYP2C9CYP2C19
SCHEMBL2283832 0.82 CYP3A4 (0.49) CYP19A1MAOAMAOBPSMB5ESR2
SCHEMBL5088610 0.81 CYP19A1 (0.47) CYP19A1MAOAMAOBPSMB5ESR2
SCHEMBL19746 0.81 CYP19A1 (0.45) CYP19A1MAOAMAOBARHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 440 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025091065-A1 FLAVONOID COMPOSITION GRETALS AUSTRALIA PTY LTD (AU) 2025-05-08 WO claimed
US-20240373850-A1 Compositions comprising resinous exudate metabolites from plants of the genus Adesmia, used to control and treat infections in plant crops; and methods for controlling infections in plant crops. PONTIFICIA UNIV CATOLICA DE VALPARAISO (CL) 2024-11-14 US claimed
CN-117242185-A Biocatalytic preparation of dihydrochalcone 西姆莱斯有限公司 2023-12-15 CN claimed
CN-116660543-A Diagnostic and prognostic markers for nonalcoholic fatty liver disease and uses thereof 中国人民解放军陆军军医大学第一附属医院 2023-08-29 CN claimed
US-20230172901-A1 COMPOSITIONS AND METHODS FOR THE PROPHYLAXIS AND TREATMENT OF FIBROTIC AND INFLAMMATORY CONDITIONS GRETALS AUSTRALIA PTY LTD (AU) 2023-06-08 US claimed
EP-4146194-A1 COMPOSITIONS AND METHODS FOR THE PROPHYLAXIS AND TREATMENT OF FIBROTIC AND INFLAMMATORY CONDITIONS Gretals Australia Pty Ltd (AU) 2023-03-15 EP claimed
WO-2022221968-A1 COMPOSITIONS COMPRISING RESINOUS EXUDATE METABOLITES FROM PLANTS OF THE GENUS ADESMIA, USED TO CONTROL AND TREAT INFECTIONS IN PLANT CROPS; AND METHODS FOR CONTROLLING INFECTIONS IN PLANT CROPS PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO (CL) 2022-10-27 WO claimed
WO-2021222987-A1 COMPOSITIONS AND METHODS FOR THE PROPHYLAXIS AND TREATMENT OF FIBROTIC AND INFLAMMATORY CONDITIONS GRETALS AUSTRALIA PTY LTD (AU) 2021-11-11 WO claimed
US-11040079-B2 Compositions derived from Galenia Africana and methods of use for cancer treatment BIOPHARM NZ LIMITED (NZ) 2021-06-22 US claimed
CN-112716933-A Application of 7-hydroxyflavanone in preparation of medicine for promoting juvenile bone growth 河南省洛阳正骨医院(河南省骨科医院) 2021-04-30 CN claimed
EP-3558333-A1 COMPOSITIONS DERIVED FROMGALENIA AFRICANA Biopharm NZ Limited (NZ) 2019-10-30 EP claimed
WO-2018116146-A1 COMPOSITIONS DERIVED FROM GALENIA AFRICANA AND METHODS OF USE FOR CANCER TREATMENT BIOPHARM NZ LIMITED (NZ) 2018-06-28 WO claimed
US-20110020895-A1 METHODS AND COMPOSITIONS FOR DETERMINING ISOMERASE ENZYMATIC ACTIVITY SALK INSTITUTE FOR BIOLOGICAL STUDIES 2011-01-27 US claimed
US-20080254519-A1 Process for Producing Picolinic Acid Compounds SHINDO KAZUTOSHI 2008-10-16 US claimed
EP-1726645-A1 PROCESS FOR PRODUCING PICOLINIC ACID COMPOUNDS MARINE BIOTECHNOLOGY INSTITUTE CO., LTD. (JP) 2006-11-29 EP claimed
US-20040096955-A1 Methods and compositions for determining isomerase enzymatic activity NATIONAL SCIENCE FOUNDATION 2004-05-20 US claimed
WO-2002018604-A2 METHODS AND COMPOSITIONS FOR DETERMINING ISOMERASE ENZYMATIC ACTIVITY THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2002-03-07 WO claimed
US-20260033492-A1 Pest Repellents and Uses Thereof SENSORYGEN INC (US) 2026-02-05 US disclosed
US-4376123-A Hexahydroazepinyloxy-chromones useful as antidepressants MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1983-03-08 US disclosed
EP-0031885-A1 Basic ethers, pharmaceutical compositions containing them and process for their preparation MERCK PATENT GmbH (DE) 1981-07-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240373850-A1 Compositions comprising resinous exudate metabolites from plants of the genus Adesmia, used to control and treat infections in plant crops; and methods for controlling infections in plant crops. ERG28, RXFP4, CROCC CYP19A1 2372/4885MAOA 2174/4885MAOB 2261/4885
US-20260033492-A1 Pest Repellents and Uses Thereof F3, TFPI, FLI1 CYP19A1 2958/4885MAOA 602/4885MAOB 1790/4885
US-20080254519-A1 Process for Producing Picolinic Acid Compounds HPD, PAH, DHPS CYP19A1 126/4885MAOA 187/4885MAOB 294/4885
US-20230172901-A1 COMPOSITIONS AND METHODS FOR THE PROPHYLAXIS AND TREATMENT OF FIBROTIC AND INFLAMMATORY CONDITIONS MMP1, COL1A1, SERPINB1 CYP19A1 3035/4885MAOA 2155/4885MAOB 2184/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.