Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | FNTA | P49354 | 2/20 | 0.40 |
| ▸ | FNTB | P49356 | 2/20 | 0.40 |
| ▸ | HAAO | P46952 | 1/20 | 0.40 |
| ▸ | MYC | P01106 | 8/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9127844 | 0.81 | HAAO (0.54) | KDM4EFNTAFNTBHAAOMYC | |
| SCHEMBL10361544 | 0.80 | KDM4E (0.64) | KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL17397300 | 0.75 | PIK3CD (0.42) | KDM4EFNTAFNTBMYCNR4A1 | |
| SCHEMBL9128607 | 0.72 | KDM4E (0.51) | KDM4EFNTAFNTBMYCALDH1A1 | |
| SCHEMBL10741119 | 0.71 | WDR5 (0.43) | KDM4ENR4A1ALDH1A1HPGD | |
| SCHEMBL17397188 | 0.71 | PIK3CD (0.41) | KDM4EALDH1A1HPGDHSD17B10HTT | |
| SCHEMBL7169839 | 0.70 | KDM4E (0.37) | KDM4EALDH1A1HPGDHTT | |
| SCHEMBL12168771 | 0.68 | HAAO (0.50) | HAAOMYCNR4A1ALDH1A1NOTUM | |
| SCHEMBL1290242 | 0.68 | KDM4E (0.43) | KDM4EFNTAFNTBALDH1A1HPGD | |
| SCHEMBL17397181 | 0.68 | KDM4E (0.39) | KDM4EFNTAFNTBALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0157346-B1 | QUINOLIZINONE COMPOUND, PROCESSES FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-01-31 | — | — | EP | disclosed |
| US-4698349-A | Quinolizinone compounds, and pharmaceutical composition comprising the same, useful as anti-ulcerative and anti-allergic agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-10-06 | — | — | US | disclosed |
| US-4650804-A | TETRAZOLYLCARBAMOYL DERIVATIVE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-03-17 | — | — | US | disclosed |
| EP-0157346-A2 | Quinolizinone compound, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-10-09 | — | — | EP | disclosed |