Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 11/20 | 0.66 |
| ▸ | DYRK1B | Q9Y463 | 8/20 | 0.59 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10379883 | 0.94 | DYRK1A (0.72) | DYRK1ADYRK1BROCK2ROCK1ALDH1A1 | |
| SCHEMBL10362828 | 0.93 | DYRK1A (0.66) | DYRK1ADYRK1BSRD5A1SRD5A2ALDH1A1 | |
| SCHEMBL10380729 | 0.92 | DYRK1A (0.66) | DYRK1ADYRK1BROCK2ROCK1ALDH1A1 | |
| SCHEMBL11952533 | 0.91 | DYRK1A (0.67) | DYRK1ADYRK1BROCK2ROCK1ALDH1A1 | |
| SCHEMBL10361589 | 0.90 | DYRK1A (0.64) | DYRK1ADYRK1BROCK2ROCK1ALDH1A1 | |
| SCHEMBL10362982 | 0.89 | DYRK1A (0.69) | DYRK1ADYRK1BROCK2ROCK1ALDH1A1 | |
| SCHEMBL10381960 | 0.89 | DYRK1A (0.72) | DYRK1ADYRK1BALDH1A1MEN1KMT2A | |
| SCHEMBL10380497 | 0.85 | DYRK1A (0.81) | DYRK1ADYRK1BROCK2ROCK1ALDH1A1 | |
| SCHEMBL10319618 | 0.85 | DYRK1A (0.67) | DYRK1ADYRK1BROCK2ROCK1 | |
| SCHEMBL10331222 | 0.84 | DYRK1A (0.66) | DYRK1ADYRK1BROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012098070-A1 | QUINOLINE DYRK1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |
| US-20120184548-A1 | CARBOXYLIC ACID ARYL AMIDES | DOMINIQUE ROMYR (US) | 2012-07-19 | — | — | US | disclosed |
| US-20120184548-A1 | CARBOXYLIC ACID ARYL AMIDES | DOMINIQUE ROMYR (US) | 2012-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184548-A1 | CARBOXYLIC ACID ARYL AMIDES | GOT1, PPARG, PPARA | DYRK1A 2480/4885DYRK1B 3023/4885SRD5A1 912/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.