GOT1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL2228008	0.70	15/20
SCHEMBL1537795	0.59	15/20
SCHEMBL2354773	0.60	13/20
SCHEMBL1570271	0.57	13/20
SCHEMBL2867435	0.43	12/20
SCHEMBL1450182	0.53	11/20
SCHEMBL2161626	0.52	11/20
SCHEMBL1105118	0.51	9/20
SCHEMBL734585	0.81	8/20
SCHEMBL3208122	0.52	7/20
SCHEMBL2676072	0.47	7/20
SCHEMBL3714943	0.47	7/20
SCHEMBL3296720	0.42	7/20
SCHEMBL1012802	0.52	6/20
SCHEMBL2953569	0.49	6/20
SCHEMBL3603629	0.50	5/20
SCHEMBL3598658	0.49	5/20
SCHEMBL1076797	0.57	4/20
SCHEMBL2163033	0.57	4/20
SCHEMBL2789684	0.52	4/20

Clinical trials — most relevant to GOT1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Hepato-renal Regulation of Water Conservation in Heart Failure Patients With SGLT-2 Inhibitor Treatment	PHASE4	COMPLETED
Comparing the Effects of Vitamin E, Ursodeoxycholic Acid and Pentoxyfylline on Egyptian Non-alcoholic Steatohepatitis (NASH) Patients	PHASE4	COMPLETED
Effectiveness of Inactive Vitamin D Supplementation in Non-Alcoholic Fatty Liver Disease Patients	PHASE3	UNKNOWN
Comparative Analysis Between Ringer's Lactate vs Plasma Lyte-A as Cardiopulmonary Bypass Prime	PHASE3	UNKNOWN
Immunotherapy With Racotumomab in Advanced Lung Cancer	PHASE3	UNKNOWN
Overcoming Primary Resistance to Immunotherapy in Metastatic Melanoma	PHASE2	COMPLETED
An Extension Study to Determine the Safety and Anti-Leukemic Effects of Imatinib Mesylate in Adult Participants With Ph+ Leukemia	PHASE2	COMPLETED
Effect of Acetaminophen and N-Acetylcysteine on Liver Metabolism on Homocystinuria	PHASE1/PHASE2	SUSPENDED
Effect of Tulsi (Ocimum Sanctum) on Biochemical Parameters in Young Overweight and Obese Subjects	PHASE2	COMPLETED
A Phase II Trial of Sutent (Sunitinib; SU011248) for Recurrent Anaplastic Astrocytoma and Glioblastoma	PHASE2	COMPLETED
Vemurafenib Plus Cobimetinib Plus PEG-interferon in Advanced Melanoma Patients Harboring the V600BRAF Mutation	PHASE1/PHASE2	COMPLETED
Placebo Controlled, Multiple Dose Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SAP-001 in Gout Patients	PHASE2	COMPLETED
A Safety and Feasibility Study of IS-001 Injection in Patients Undergoing Robotic Colorectal Surgery	PHASE2	COMPLETED
Probing the Synergistic Effect of Pre-Biotics & Iron Fortificants in Anemic Subjects	PHASE1/PHASE2	COMPLETED
BTK Inhibitor DTRMWXHS-12 in Mantle Cell Lymphoma	PHASE1	COMPLETED
Investigating Senolytic Properties in Pulmonary Rehabilitation and Metformin in COPD Exacerbations	PHASE1	NOT_YET_RECRUITING
Single Ascending and Multiple Dose Study to Evaluate Safety, Tolerability, and PK of MYMD1 in Healthy Male and Female Adult Subjects	PHASE1	COMPLETED
Effect of Blueberry Supplementation on Liver Enzymes, Muscle Injury and Respiratory Parameter in Football Athletes: A Eight-Week Training Study	nan	COMPLETED
Predicts Mortality by AST/ALT Ration in Patients with Sepsis and Septic Shock During ICU Admissin	nan	NOT_YET_RECRUITING
Prevalence of HBV in Pregnant Women Attending Antenatal Care in Tanzania	nan	COMPLETED
Acute Hepatitis in Pediatrics	nan	RECRUITING
Glutamate Excitotoxicity in Brain Metastases From Lung, Breast and Melanoma Treated With Stereotactic Radiosurgery	nan	ACTIVE_NOT_RECRUITING
Markers of Liver Apoptosis After Anesthesia With Sevoflurane or Propofol	nan	COMPLETED
SRT in Comparison to ERT on Immune Aspects and Bone Involvement in Gaucher Disease	nan	UNKNOWN
Role of the Liver in Glucose Homeostasis Using Metabolic Imaging	nan	COMPLETED
Mediterranean Lifestyle Intervention in Patients With Non-alcoholic Fatty Liver Disease	nan	COMPLETED
The Study to Investigate the Contribution of Basal and Postprandial Glucose to Overall Hyperglycemia in T2DM	nan	COMPLETED
Screening of Lysosomal Storage Disorders Diseases in Minority Groups	nan	UNKNOWN
Liver Function Abnormalities in Patients With Acute Heart Failure	nan	NOT_YET_RECRUITING
High Throughput Drug Sensitivity Assay and Genomics- Guided Treatment of Patients With Relapsed or Refractory Acute Leukemia	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a GOT1 binder may also engage these)

Protein	Name	Similarity
A5A6K8	—	1.000	A5A6K8 →
Q5R691	—	1.000	Q5R691 →
P13221	—	1.000	P13221 →
Q4R5L1	—	1.000	Q4R5L1 →
P33097	—	1.000	P33097 →
P08906	—	1.000	P08906 →
P00503	—	1.000	P00503 →
P05201	—	0.998	P05201 →
P00504	—	0.996	P00504 →
P37833	—	0.970	P37833 →
P28734	—	0.966	P28734 →
P54767	—	0.963	P54767 →
Q9ZPS4	—	0.962	Q9ZPS4 →
P28011	—	0.962	P28011 →
AADAT	Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	0.962	landscape →
Q5E9N4	—	0.960	Q5E9N4 →
Q9LSH2	—	0.957	Q9LSH2 →
P36871	—	0.956	P36871 →
Q4R5E4	—	0.955	Q4R5E4 →
P18757	—	0.955	P18757 →
Q9SGC1	—	0.954	Q9SGC1 →
Q9SM60	—	0.954	Q9SM60 →
Q7T3E5	—	0.954	Q7T3E5 →
Q9SNX2	—	0.954	Q9SNX2 →
Q08DP0	—	0.954	Q08DP0 →
Q71RI9	—	0.953	Q71RI9 →
B9N1F9	—	0.953	B9N1F9 →
Q6GML7	—	0.953	Q6GML7 →
A0A0K9RL25	—	0.953	A0A0K9RL25 →
P00949	—	0.953	P00949 →