Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA2 | P54646 | 19/20 | 0.46 |
| ▸ | PRKAB2 | O43741 | 8/20 | 0.44 |
| ▸ | PRKAG1 | P54619 | 8/20 | 0.44 |
| ▸ | PRKAA1 | Q13131 | 8/20 | 0.44 |
| ▸ | PRKAG3 | Q9UGI9 | 8/20 | 0.44 |
| ▸ | PRKAG2 | Q9UGJ0 | 8/20 | 0.44 |
| ▸ | PRKAB1 | Q9Y478 | 8/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2507821 | 0.87 | PRKAA2 (0.60) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL12199876 | 0.83 | PRKAA2 (0.56) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL1036284 | 0.81 | PRKAA2 (0.54) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL12199879 | 0.81 | PRKAA2 (0.54) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL3801004 | 0.81 | PRKAA2 (0.53) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL3667019 | 0.81 | PRKAA2 (0.49) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL3799739 | 0.80 | PRKAA2 (0.51) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL3665359 | 0.79 | UTS2R (0.45) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL3662808 | 0.79 | PRKAA2 (0.46) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL4430744 | 0.79 | PRKAA2 (0.46) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276761-A1 | CARBOXAMIDE COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2011-01-26 | — | — | EP | disclosed |
| WO-2009132136-A1 | CARBOXAMIDE COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | disclosed |