Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA2 | P54646 | 20/20 | 0.51 |
| ▸ | PRKAB2 | O43741 | 7/20 | 0.50 |
| ▸ | PRKAG1 | P54619 | 7/20 | 0.50 |
| ▸ | PRKAA1 | Q13131 | 7/20 | 0.50 |
| ▸ | PRKAG3 | Q9UGI9 | 7/20 | 0.50 |
| ▸ | PRKAG2 | Q9UGJ0 | 7/20 | 0.50 |
| ▸ | PRKAB1 | Q9Y478 | 7/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3798034 | 0.89 | SLC6A5 (0.50) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL648252 | 0.89 | PRKAA2 (0.65) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL3801004 | 0.88 | PRKAA2 (0.53) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL4430744 | 0.81 | PRKAA2 (0.46) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL647029 | 0.81 | PRKAA2 (0.69) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL647386 | 0.81 | PRKAA2 (0.75) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL1036306 | 0.80 | PRKAA2 (0.46) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL3664005 | 0.80 | PRKAA2 (0.45) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 | |
| SCHEMBL3665414 | 0.78 | SLC6A5 (0.50) | — | |
| SCHEMBL3662808 | 0.77 | PRKAA2 (0.46) | PRKAA2PRKAB2PRKAG1PRKAA1PRKAG3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231600-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009065131-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | claimed |