Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 10/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 5/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 2/20 | 0.35 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10363996 | 0.85 | PDE3B (0.47) | PDE3BPDE3ACRBNTBXAS1PDE4A | |
| SCHEMBL10364002 | 0.82 | PDE3B (0.42) | PDE3BPDE3ACRBNTBXAS1PDE4A | |
| SCHEMBL10363621 | 0.80 | PDE3B (0.41) | PDE3BPDE3ACRBNTBXAS1PDE4A | |
| SCHEMBL10757305 | 0.79 | PDE3B (0.54) | PDE3BPDE3ACRBNTBXAS1PDE4A | |
| SCHEMBL10648101 | 0.73 | PDE3B (0.62) | PDE3BPDE3ACRBNTBXAS1PDE4A | |
| SCHEMBL10364636 | 0.71 | PDE3B (0.48) | PDE3BPDE3ACRBNTBXAS1PDE4A | |
| SCHEMBL7340691 | 0.71 | PDE3B (0.51) | PDE3BPDE3ACRBNTBXAS1PDE4A | |
| Hydrochloric Acid SCHEMBL10367316 | 0.70 | PDE3B (0.47) | PDE3BPDE3ACRBNTBXAS1PDE4A | |
| SCHEMBL10365680 | 0.70 | PDE4A (0.43) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10730608 | 0.70 | PDE3B (0.67) | PDE3BPDE3ACRBNPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0175187-B1 | 3,4-DIHYDRO-2(1H)-PYRIDONES AND 2(1H)-PYRIDONES CONTAINING IMIDAZOLE GROUPS, METHOD FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | A. Nattermann & Cie. GmbH (DE) | 1990-01-10 | — | — | EP | disclosed |
| US-4699914-A | CONGESTIVE HEART FAILURE | A. NATTERMANN & CIE GMBH (DE) | 1987-10-13 | — | — | US | disclosed |
| EP-0175187-A1 | 3,4-Dihydro-2(1H)-pyridones and 2(1H)-pyridones containing imidazole groups, method for their preparation and medicaments containing them | A. Nattermann & Cie. GmbH (DE) | 1986-03-26 | — | — | EP | disclosed |