Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 13/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 13/20 | 0.54 |
| ▸ | PDE4A | P27815 | 2/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.51 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.51 |
| ▸ | PDE2A | O00408 | 2/20 | 0.50 |
| ▸ | PDE1A | P54750 | 1/20 | 0.49 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.49 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7340691 | 0.89 | PDE3B (0.51) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7450630 | 0.84 | PDE3B (0.61) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL10756530 | 0.82 | PDE3B (0.60) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10762285 | 0.81 | PDE3B (0.60) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10364014 | 0.79 | PDE3B (0.45) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10363621 | 0.79 | PDE3B (0.41) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11112991 | 0.79 | CYP19A1 (0.44) | PDE3BPDE3ACRBN | |
| SCHEMBL10759143 | 0.77 | PDE3B (0.57) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7342584 | 0.75 | PDE3B (0.49) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7341034 | 0.74 | PDE3B (0.62) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4699914-A | CONGESTIVE HEART FAILURE | A. NATTERMANN & CIE GMBH (DE) | 1987-10-13 | — | — | US | disclosed |
| EP-0175187-A1 | 3,4-Dihydro-2(1H)-pyridones and 2(1H)-pyridones containing imidazole groups, method for their preparation and medicaments containing them | A. Nattermann & Cie. GmbH (DE) | 1986-03-26 | — | — | EP | disclosed |