Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VHL | P40337 | 1/20 | 0.62 |
| ▸ | ELOC | Q15369 | 1/20 | 0.62 |
| ▸ | ELOB | Q15370 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30888626 | 0.85 | VHL (0.56) | VHLELOCELOBALDH1A1KDM4E | |
| SCHEMBL30888616 | 0.85 | VHL (0.56) | VHLELOCELOBALDH1A1KDM4E | |
| SCHEMBL22714572 | 0.81 | KDM4E (0.77) | VHLELOCELOBALDH1A1KDM4E | |
| SCHEMBL5114791 | 0.77 | VHL (0.74) | VHLELOCELOBALDH1A1KDM4E | |
| SCHEMBL69544 | 0.77 | VHL (1.00) | VHLELOCELOBALDH1A1KDM4E | |
| SCHEMBL5956835 | 0.77 | KDM4E (0.52) | VHLELOCELOBALDH1A1KDM4E | |
| SCHEMBL10363739 | 0.76 | KDM4E (0.56) | VHLELOCELOBALDH1A1KDM4E | |
| SCHEMBL9607758 | 0.76 | KDM4E (0.56) | VHLELOCELOBALDH1A1KDM4E | |
| SCHEMBL30888516 | 0.76 | KDM4E (0.56) | VHLELOCELOBALDH1A1KDM4E | |
| SCHEMBL22715017 | 0.76 | KDM4E (0.51) | VHLELOCELOBALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0212428-B1 | DIHYDROBENZO/B /THIOPHENES AND PHARMACEUTICAL COMPOSITIONS THEREOF USEFUL AS ANTIFUNGALS | SCHERING CORPORATION (US) | 1990-06-06 | — | — | EP | disclosed |
| US-4731364-A | Dihydrobenzo(B)thiophenes and pharmaceutical compositions thereof useful as antifungals | SCHERING CORPORATION (US) | 1988-03-15 | — | — | US | disclosed |
| EP-0212428-A1 | Dihydrobenzo/b /thiophenes and pharmaceutical compositions thereof useful as antifungals | SCHERING CORPORATION (US) | 1987-03-04 | — | — | EP | disclosed |
| EP-0054233-B1 | NOVEL BENZO(B)THIOPHENES, BENZO(B)FURANS, THIOCHROMANS AND CHROMANS, PROCESSES FOR THEIR PREPARATION AND ANTIMICROBIAL COMPOSITIONS CONTAINING THEM | SCHERING CORPORATION (US) | 1986-09-24 | — | — | EP | disclosed |
| US-4471124-A | DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1984-09-11 | — | — | US | disclosed |
| US-4468404-A | MICROBIOCIDES | SCHERING CORPORATION (US) | 1984-08-28 | — | — | US | disclosed |
| US-4442114-A | COMPLICATIONS OF DIABETES | PFIZER INC. (US) | 1984-04-10 | — | — | US | disclosed |
| US-4431816-A | FUNGICIDES; BACTERICIDES | SCHERING CORPORATION (US) | 1984-02-14 | — | — | US | disclosed |
| EP-0028485-B1 | SPIRO-IMIDAZOLONES FOR ALLEVIATING DIABETES-ASSOCIATED CONDITIONS, PROCESSES FOR PREPARING THEM, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PFIZER INC. (US) | 1983-08-24 | — | — | EP | disclosed |
| US-4352808-A | FUNGICIDES, BACTERICIDES, ANTIPROTOZOA AGENTS | SCHERING CORPORATION (US) | 1982-10-05 | — | — | US | disclosed |
| EP-0054233-A1 | Novel benzo(b)thiophenes, benzo(b)furans, thiochromans and chromans, processes for their preparation and antimicrobial compositions containing them | SCHERING CORPORATION (US) | 1982-06-23 | — | — | EP | disclosed |
| US-4307108-A | DIABETES | PFIZER INC. (US) | 1981-12-22 | — | — | US | disclosed |
| US-4283409-A | ANTIDIABETIC AGENTS | PFIZER INC. (US) | 1981-08-11 | — | — | US | disclosed |
| US-4282229-A | FOR DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1981-08-04 | — | — | US | disclosed |
| EP-0028485-A1 | Spiro-imidazolones for alleviating diabetes-associated conditions, processes for preparing them, and pharmaceutical compositions containing them | PFIZER INC. (US) | 1981-05-13 | — | — | EP | disclosed |
| US-4258054-A | ANTIDIABETIC | PFIZER INC. (US) | 1981-03-24 | — | — | US | disclosed |
| US-4210756-A | Tetrahydroquinoline hydantoins for chronic diabetic complications | PFIZER INC. (US) | 1980-07-01 | — | — | US | disclosed |
| US-4209630-A | ANTIDIABETIC AGENTS | PFIZER INC. (US) | 1980-06-24 | — | — | US | disclosed |
| US-4147795-A | ENZYME INHIBITORS | PFIZER INC. (US) | 1979-04-03 | — | — | US | disclosed |
| US-4117230-A | ANTIDIABETIC AGENTS | PFIZER INC. (US) | 1978-09-26 | — | — | US | disclosed |