Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.76 |
| ▸ | GAA | P10253 | 4/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | CFD | P00746 | 1/20 | 0.56 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7746192 | 0.87 | KDM4E (1.00) | KDM4EALDH1A1GAAKMT2ATSHR | |
| SCHEMBL10364665 | 0.86 | KDM4E (0.82) | KDM4EALDH1A1GAAKMT2ATSHR | |
| SCHEMBL10364579 | 0.81 | TRPV1 (0.53) | KDM4EALDH1A1GAAKMT2ATSHR | |
| SCHEMBL16127701 | 0.81 | KDM4E (0.73) | KDM4EALDH1A1GAAKMT2ATSHR | |
| SCHEMBL22114099 | 0.78 | KDM4E (0.68) | KDM4EALDH1A1GAAKMT2ATSHR | |
| SCHEMBL16127714 | 0.78 | KDM4E (0.76) | KDM4EALDH1A1GAAKMT2ATSHR | |
| SCHEMBL10746490 | 0.78 | KDM4E (0.72) | KDM4EALDH1A1GAAKMT2ATSHR | |
| SCHEMBL27481531 | 0.77 | GAA (0.63) | KDM4EALDH1A1GAAKMT2ATSHR | |
| SCHEMBL10363515 | 0.77 | GAA (1.00) | KDM4EALDH1A1GAAKMT2ATSHR | |
| SCHEMBL10362885 | 0.76 | KDM4E (0.74) | KDM4EALDH1A1GAAKMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0147211-B1 | 4H-3,1-BENZOXAZIN-4-ONES AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION | SYNTEX (U.S.A.) INC. (US) | 1990-09-12 | — | — | EP | disclosed |
| US-4657893-A | ANTIINFLAMMATORY AGENTS | SYNTEX (U.S.A.) INC. (US) | 1987-04-14 | — | — | US | disclosed |
| EP-0147211-A2 | 4H-3,1-benzoxazin-4-ones and related compounds, pharmaceutical compositions containing them, and processes for their preparation | SYNTEX (U.S.A.) INC. (US) | 1985-07-03 | — | — | EP | disclosed |