Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 1.00 |
| ▸ | GAA | P10253 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.74 |
| ▸ | TSHR | P16473 | 2/20 | 0.74 |
| ▸ | HPGD | P15428 | 1/20 | 0.74 |
| ▸ | CFD | P00746 | 1/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | GSK3B | P49841 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10364665 | 0.90 | KDM4E (0.82) | KDM4EALDH1A1GAAKMT2AHSD17B10 | |
| SCHEMBL18415451 | 0.87 | ALDH1A1 (0.77) | KDM4EALDH1A1GAAKMT2AHSD17B10 | |
| SCHEMBL16127714 | 0.87 | KDM4E (0.76) | KDM4EALDH1A1GAAKMT2AHSD17B10 | |
| SCHEMBL10364280 | 0.87 | KDM4E (0.76) | KDM4EALDH1A1GAAKMT2AHSD17B10 | |
| SCHEMBL10362772 | 0.86 | ALDH1A1 (0.75) | KDM4EALDH1A1GAAKMT2AHSD17B10 | |
| SCHEMBL10364261 | 0.85 | KDM4E (0.74) | KDM4EALDH1A1GAAKMT2AHSD17B10 | |
| SCHEMBL10363016 | 0.85 | KDM4E (0.74) | KDM4EALDH1A1GAAKMT2AHSD17B10 | |
| SCHEMBL10362885 | 0.85 | KDM4E (0.74) | KDM4EALDH1A1GAAKMT2AHSD17B10 | |
| SCHEMBL16127701 | 0.85 | KDM4E (0.73) | KDM4EALDH1A1GAAKMT2AHSD17B10 | |
| SCHEMBL22524974 | 0.84 | ALDH1A1 (0.72) | KDM4EALDH1A1GAAKMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111763164-B | Preparation method and application of ortho-carbonyl amino substituted benzene derivatives | 中国医学科学院药物研究所 | 2023-03-10 | — | — | CN | disclosed |
| CN-111763164-A | Preparation method and application of ortho-carbonyl amino substituted benzene derivatives | 中国医学科学院药物研究所 | 2020-10-13 | — | — | CN | disclosed |
| WO-2020199945-A1 | ORTHO-CARBONYL AMINO-SUBSTITUTED BENZENE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 中国医学科学院药物研究所 | 2020-10-08 | — | — | WO | disclosed |
| EP-0712849-B1 | Process of preparation of substituted quinazolin-2,4-diones | CLARIANT GMBH (DE) | 2001-01-17 | — | — | EP | disclosed |
| US-5710319-A | Process for the preparation of substituted quinazoline-2,4-diones | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-01-20 | — | — | US | disclosed |
| EP-0712849-A2 | Process of preparation of substituted quinazolin-2,4-diones | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-05-22 | — | — | EP | disclosed |
| EP-0147211-B1 | 4H-3,1-BENZOXAZIN-4-ONES AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION | SYNTEX (U.S.A.) INC. (US) | 1990-09-12 | — | — | EP | disclosed |
| US-4657893-A | ANTIINFLAMMATORY AGENTS | SYNTEX (U.S.A.) INC. (US) | 1987-04-14 | — | — | US | disclosed |
| EP-0147211-A2 | 4H-3,1-benzoxazin-4-ones and related compounds, pharmaceutical compositions containing them, and processes for their preparation | SYNTEX (U.S.A.) INC. (US) | 1985-07-03 | — | — | EP | disclosed |