Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 14/20 | 0.57 |
| ▸ | PPARA | Q07869 | 10/20 | 0.57 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.56 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10367689 | 0.92 | PPARG (0.60) | PPARGPPARACYP3A4CYP2C9KCNH2 | |
| SCHEMBL6531845 | 0.91 | PPARG (0.61) | PPARGPPARAFFAR1KDR | |
| SCHEMBL6959897 | 0.88 | KDR (0.47) | PPARGPPARAFFAR1MAOBKDR | |
| SCHEMBL10365888 | 0.85 | PPARG (0.52) | PPARGPPARACYP3A4CYP2C9KCNH2 | |
| SCHEMBL10366694 | 0.83 | MAOB (0.47) | PPARGPPARAFFAR1MAOBCYP3A4 | |
| SCHEMBL4283015 | 0.83 | PPARG (0.63) | PPARGPPARACYP3A4CYP2C9KCNH2 | |
| SCHEMBL170065 | 0.83 | PPARG (0.63) | PPARGPPARACYP3A4CYP2C9KCNH2 | |
| SCHEMBL8140646 | 0.81 | PPARG (0.59) | PPARGPPARA | |
| SCHEMBL6968334 | 0.81 | FFAR1 (0.63) | PPARGPPARAFFAR1KDR | |
| SCHEMBL8461494 | 0.81 | FFAR1 (0.60) | PPARGPPARAFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0177353-B1 | THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1990-04-11 | — | — | EP | disclosed |
| US-4725610-A | TREATMENT OF HYPERLIPEMIA AND DIABETES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1988-02-16 | — | — | US | disclosed |
| EP-0177353-A2 | Thiazolidinedione derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1986-04-09 | — | — | EP | disclosed |