Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 20/20 | 0.60 |
| ▸ | PPARA | Q07869 | 15/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.55 |
| ▸ | PPARD | Q03181 | 5/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10365888 | 0.92 | PPARG (0.52) | PPARGPPARACYP2C9CYP3A4KCNH2 | |
| SCHEMBL10364877 | 0.92 | PPARG (0.57) | PPARGPPARACYP2C9CYP3A4KCNH2 | |
| SCHEMBL4283015 | 0.92 | PPARG (0.63) | PPARGPPARACYP2C9CYP3A4KCNH2 | |
| SCHEMBL170065 | 0.92 | PPARG (0.63) | PPARGPPARACYP2C9CYP3A4KCNH2 | |
| SCHEMBL8140646 | 0.90 | PPARG (0.59) | PPARGPPARA | |
| SCHEMBL10366928 | 0.88 | PPARG (0.48) | PPARGPPARACYP2C9CYP3A4KCNH2 | |
| SCHEMBL10858398 | 0.88 | PPARG (0.47) | PPARGPPARACYP2C9CYP3A4KCNH2 | |
| SCHEMBL10364912 | 0.88 | PPARG (0.54) | PPARGPPARACYP2C9CYP3A4KCNH2 | |
| SCHEMBL10861819 | 0.87 | PPARG (0.56) | PPARGPPARACYP2C9CYP3A4KCNH2 | |
| SCHEMBL10366694 | 0.84 | MAOB (0.47) | PPARGPPARACYP2C9CYP3A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0177353-B1 | THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1990-04-11 | — | — | EP | disclosed |
| US-4725610-A | TREATMENT OF HYPERLIPEMIA AND DIABETES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1988-02-16 | — | — | US | disclosed |
| EP-0177353-A2 | Thiazolidinedione derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1986-04-09 | — | — | EP | disclosed |