Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 10/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.47 |
| ▸ | PDE2A | O00408 | 2/20 | 0.47 |
| ▸ | PDE1A | P54750 | 1/20 | 0.47 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.47 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.31 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10366391 | 0.99 | PDE3B (0.46) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10364522 | 0.86 | PDE3B (0.40) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10365668 | 0.80 | PDE3B (0.43) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10363627 | 0.80 | PDE3B (0.42) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10364636 | 0.79 | PDE3B (0.48) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10651787 | 0.78 | PDE3B (0.63) | PDE3BPDE3APDE2APDE1APDE1B | |
| Hydrochloric Acid SCHEMBL10367316 | 0.78 | PDE3B (0.47) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10761383 | 0.78 | PDE3B (0.73) | PDE3BPDE3APDE2APDE1APDE1B | |
| Hydrochloric Acid SCHEMBL10757069 | 0.77 | PDE3B (0.72) | PDE3BPDE3APDE2APDE1APDE1B | |
| SCHEMBL10646114 | 0.74 | PDE3A (0.63) | PDE3BPDE3APDE2APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0175187-B1 | 3,4-DIHYDRO-2(1H)-PYRIDONES AND 2(1H)-PYRIDONES CONTAINING IMIDAZOLE GROUPS, METHOD FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | A. Nattermann & Cie. GmbH (DE) | 1990-01-10 | — | — | EP | disclosed |
| US-4699914-A | CONGESTIVE HEART FAILURE | A. NATTERMANN & CIE GMBH (DE) | 1987-10-13 | — | — | US | disclosed |
| EP-0175187-A1 | 3,4-Dihydro-2(1H)-pyridones and 2(1H)-pyridones containing imidazole groups, method for their preparation and medicaments containing them | A. Nattermann & Cie. GmbH (DE) | 1986-03-26 | — | — | EP | disclosed |