Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 3/20 | 0.37 |
| ▸ | TDO2 | P48775 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5482781 | 0.92 | MEN1 (0.42) | MEN1KMT2AIDO1TDO2ALDH1A1 | |
| SCHEMBL2676471 | 0.92 | MEN1 (0.42) | MEN1KMT2AIDO1TDO2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL14862500 | 0.90 | IDO1 (0.42) | MEN1KMT2AIDO1TDO2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL16292824 | 0.90 | IDO1 (0.42) | MEN1KMT2AIDO1TDO2ALDH1A1 | |
| SCHEMBL31521318 | 0.74 | PDCD1LG2 (0.42) | EPHX1ALDH1A1CYP3A4 | |
| SCHEMBL1494144 | 0.74 | CA1 (0.41) | IDO1TDO2ALDH1A1 | |
| SCHEMBL31521342 | 0.74 | PDCD1LG2 (0.42) | EPHX1ALDH1A1CYP3A4 | |
| SCHEMBL31521383 | 0.74 | PDCD1LG2 (0.42) | EPHX1ALDH1A1CYP3A4 | |
| SCHEMBL14862496 | 0.73 | OPRL1 (0.39) | IDO1TDO2ALDH1A1CYP3A4 | |
| SCHEMBL20217301 | 0.73 | KMT2A (0.43) | EPHX1MEN1KMT2AALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130190499-A1 | Azaisoquinolinone derivatives as NK3 antagonists | H. LUNDBECK A/S (DK) | 2013-07-25 | — | — | US | claimed |
| US-8420667-B2 | Isoquinolinone derivatives as NK3 antagonists | H. LUNDBECK A/S (DK) | 2013-04-16 | — | — | US | claimed |
| EP-2545053-A1 | AZAISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | H. Lundbeck A/S (DK) | 2013-01-16 | — | — | EP | claimed |
| EP-2513061-A1 | PYRIDONE DERIVATIVES AS NK3 ANTAGONISTS | H. Lundbeck A/S (DK) | 2012-10-24 | — | — | EP | claimed |
| US-8207347-B2 | Pyridone derivatives as NK3 antagonists | H. LUNDBECK A/S (DK) | 2012-06-26 | — | — | US | claimed |
| EP-2276741-A1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | H. Lundbeck A/S (DK) | 2011-01-26 | — | — | EP | claimed |
| EP-2150534-A1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | H. Lundbeck A/S (DK) | 2010-02-10 | — | — | EP | claimed |
| WO-2009130240-A1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | H. LUNDBECK A/S (DK) | 2009-10-29 | — | — | WO | claimed |
| US-20090143402-A1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | H. LUNDBECK A/S (DK) | 2009-06-04 | — | — | US | claimed |
| WO-2008131779-A1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | H. LUNDBECK A/S (DK) | 2008-11-06 | — | — | WO | claimed |
| US-20130190499-A1 | Azaisoquinolinone derivatives as NK3 antagonists | H. LUNDBECK A/S (DK) | 2013-07-25 | — | — | US | disclosed |
| US-20130190499-A1 | Azaisoquinolinone derivatives as NK3 antagonists | H. LUNDBECK A/S (DK) | 2013-07-25 | — | — | US | disclosed |
| US-20130190499-A1 | Azaisoquinolinone derivatives as NK3 antagonists | H. LUNDBECK A/S (DK) | 2013-07-25 | — | — | US | disclosed |
| US-8420667-B2 | Isoquinolinone derivatives as NK3 antagonists | H. LUNDBECK A/S (DK) | 2013-04-16 | — | — | US | disclosed |
| EP-2545053-A1 | AZAISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | H. Lundbeck A/S (DK) | 2013-01-16 | — | — | EP | disclosed |
| US-20090143402-A1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | H. LUNDBECK A/S (DK) | 2009-06-04 | — | — | US | disclosed |
| US-20090143402-A1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | H. LUNDBECK A/S (DK) | 2009-06-04 | — | — | US | disclosed |
| US-20090143402-A1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | H. LUNDBECK A/S (DK) | 2009-06-04 | — | — | US | disclosed |
| WO-2008131779-A1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | H. LUNDBECK A/S (DK) | 2008-11-06 | — | — | WO | disclosed |
| WO-2008131779-A1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | H. LUNDBECK A/S (DK) | 2008-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143402-A1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | KCNQ3, KCNK3, GRIK3 | EPHX1 1666/4885MEN1 3960/4885KMT2A 1850/4885 |
| US-20130190499-A1 | Azaisoquinolinone derivatives as NK3 antagonists | KCNQ3, KCNK3, KCND3 | EPHX1 2341/4885MEN1 1544/4885KMT2A 341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.