GRIK3

Glutamate receptor ionotropic, kainate 3 · Q13003 · GRIK3 on Sugi Atlas →

20,324 patent compounds predicted against GRIK3, 13,780 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Fanapanel (SCHEMBL353357)	0.48	5/20
Aspartic Acid (SCHEMBL135731)	0.57	4/20
Aspartic Acid (SCHEMBL464907)	0.50	4/20
Aspartic Acid (SCHEMBL464908)	0.50	4/20
Aspartic Acid (SCHEMBL305804)	0.48	4/20
Aspartic Acid (SCHEMBL305805)	0.48	4/20
Asparagine (SCHEMBL15460)	0.46	4/20
Asparagine (SCHEMBL38379)	0.46	4/20
Asparagine (SCHEMBL150535)	0.46	4/20
Asparagine (SCHEMBL288093)	0.46	4/20
Asparagine (SCHEMBL288094)	0.46	4/20
Asparagine (SCHEMBL289546)	0.46	4/20
Asparagine (SCHEMBL50254)	0.45	4/20
Asparagine (SCHEMBL50255)	0.45	4/20
Aspartic Acid (SCHEMBL379367)	0.38	4/20
Nbqx (SCHEMBL120375)	1.00	3/20
SCHEMBL380601	0.50	3/20
SCHEMBL434918	0.50	3/20
SCHEMBL434919	0.50	3/20
Asparagine (SCHEMBL286918)	0.48	3/20

Clinical trials — most relevant to GRIK3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Treatment of Cognitive and Negative Symptoms in Schizophrenia With N-acetylcysteine	PHASE4	COMPLETED
Memantine for Refractory OCD Patients	PHASE3	UNKNOWN
Prehospital Early Administration of Ketamine for Status Epilepticus in Epileptic Kids (PEAK-SEEK)	PHASE2/PHASE3	RECRUITING
A Randomized, Double-Blind Controlled Comparison of NRX-101 vs. Placebo for Adults Being Treated With Robotic Transcranial Magnetic Stimulation for Treatment Resistant Depression: The SPARC-TMS Trial	PHASE2/PHASE3	NOT_YET_RECRUITING
A Randomized, Clinical Trial of Vitamin E and Memantine in Alzheimer's Disease	PHASE3	COMPLETED
TAP-GRIN: Interventional Study on Patients With GRIN-related Neurodevelopmental Disorders	PHASE3	RECRUITING
Leveraging Biomarkers for Personalized Treatment of Alcohol Use Disorder Comorbid With PTSD	PHASE2	RECRUITING
Neurobiology of a Mutation in Glycine Metabolism in Psychotic Disorders	PHASE2	COMPLETED
Effect of Sarcosine on Symptomatology, Quality of Life, Oxidative Stress and Glutamatergic Parameters in Schizophrenia	PHASE2	COMPLETED
Effects of Direct Transcranial Current Stimulation on Central Neural Pain Processing in Fibromyalgia	PHASE1/PHASE2	COMPLETED
Antidepressant Effects of the Glycine Receptor Antagonist AV-101 (4-chlorokynurenine) in Major Depressive Disorder	PHASE2	COMPLETED
Brain Imaging, Genetics and Treatment for Major Depression	PHASE1	WITHDRAWN
Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response, Pilot Trial	PHASE1	COMPLETED
Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response	PHASE1	RECRUITING
PET Imaging of Brain mGluR5 Receptors Using [18F]SP203	PHASE1	COMPLETED
N-acetylcysteine (NAC) for Improving Cognitive Dysfunction in Schizophrenia	PHASE1	COMPLETED
D-aspartate and Therapeutic Exercise	EARLY_PHASE1	UNKNOWN
Targeting a Genetic Mutation in Glycine Metabolism With D-cycloserine	EARLY_PHASE1	COMPLETED
Integrins and Protocadherins in Glutamatergic Circuits: Identification of Common Signaling Pathways and Molecular Targets in Anxiety and Major Depressive Disorders (GAPsy)	nan	UNKNOWN
Tolerability and Efficacy of L-Serine in Patients With GRIN-related Encephalopathy	nan	UNKNOWN
The Impact of Pharmacological and Electric Modulation of NMDA Pathway on the Cognitive Flexibility and Volitional Movement Preparation in Patients With Parkinson's Disease	nan	COMPLETED
The Neuroprotective Effect of Dexmedetomidine Preserving Brain Functional Connectivity in Elderly Patients	nan	COMPLETED
An Assessment of Cognitive Function in Irritable Bowel Syndrome	nan	UNKNOWN
Metabotropic Receptors For Glutamate Type 3 In Parkinson's	nan	UNKNOWN
(GluEsk) Glutamate and Esketamine	nan	COMPLETED
PET Imaging of Brain mGluR1 Receptors Using [18F]FIMX	nan	COMPLETED
7 Tesla MRI Brain Imaging to Decipher Filgotinib's Mode of Analgesic Action in Rheumatoid Arthritis	nan	RECRUITING
Genetic Predictors of Lithium Response in Bipolar Disorder	nan	COMPLETED
Exploiting Leading Edge 7T MRI Brain Imaging to Decipher Olumiant's Mode of Analgesic Action in Rheumatoid Arthritis	nan	COMPLETED
Mechanisms of Human Plasticity in the Human System	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a GRIK3 binder may also engage these)

Protein	Name	Similarity
Q38PU2	—	1.000	Q38PU2 →
B1AS29	—	1.000	B1AS29 →
P42264	—	1.000	P42264 →
Q38PU3	—	1.000	Q38PU3 →
P39087	—	1.000	P39087 →
P42260	—	1.000	P42260 →
Q9Z2W8	—	1.000	Q9Z2W8 →
GRIK2	Glutamate receptor ionotropic, kainate 2	1.000	landscape →
Q91755	—	1.000	Q91755 →
A0A2R8QF68	—	1.000	A0A2R8QF68 →
GRIA4	Glutamate receptor 4	1.000	landscape →
GRIK1	Glutamate receptor ionotropic, kainate 1	1.000	landscape →
Q60934	—	1.000	Q60934 →
GRIA2	Glutamate receptor 2	0.999	landscape →
Q38PU5	—	0.999	Q38PU5 →
GRIA1	Glutamate receptor 1	0.999	landscape →
Q38PU4	—	0.998	Q38PU4 →
P26591	—	0.998	P26591 →
P19492	—	0.997	P19492 →
P19493	—	0.997	P19493 →
P23819	—	0.997	P23819 →
P19490	—	0.997	P19490 →
Q38PU8	—	0.997	Q38PU8 →
Q01812	—	0.997	Q01812 →
Q5R4M0	—	0.997	Q5R4M0 →
P22756	—	0.996	P22756 →
GRIA3	Glutamate receptor 3	0.996	landscape →
P19491	—	0.995	P19491 →
P23818	—	0.995	P23818 →
Q5IS46	—	0.995	Q5IS46 →