Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10909763 | 0.85 | RECQL (0.49) | RECQLMEN1ALDH1A1LMNAMAPT | |
| Hydrochloric Acid SCHEMBL10366206 | 0.84 | RECQL (0.48) | RECQLMEN1ALDH1A1LMNAMAPT | |
| Bromide SCHEMBL10365710 | 0.84 | RECQL (0.48) | RECQLMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL10909580 | 0.82 | RECQL (0.47) | RECQLMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL10366987 | 0.82 | ALDH1A1 (0.51) | RECQLMEN1ALDH1A1LMNAMAPT | |
| Bromide SCHEMBL10366163 | 0.74 | ALDH1A1 (0.50) | RECQLMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL10374343 | 0.74 | PPARG (0.41) | RECQLMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL27864695 | 0.71 | ALDH1A1 (0.58) | RECQLMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL10909332 | 0.70 | MEN1 (0.46) | RECQLMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL10007663 | 0.69 | MEN1 (0.50) | MEN1ALDH1A1KMT2ASMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4588727-A | ANALGESICS, TRANQUILLIZERS, ANTICONVULSANTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1986-05-13 | — | — | US | claimed |
| EP-0167922-B1 | Pyrrolo [1,2-b] [1,2,5] triazepines, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1990-03-28 | — | — | EP | disclosed |
| US-4588727-A | ANALGESICS, TRANQUILLIZERS, ANTICONVULSANTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1986-05-13 | — | — | US | disclosed |
| EP-0167922-A2 | Pyrrolo [1,2-b] [1,2,5] triazepines, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1986-01-15 | — | — | EP | disclosed |
| US-4517195-A | ANALGESICS, ANXIETY, ANTICONVULSANTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-05-14 | — | — | US | disclosed |