Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 7/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10366133 | 0.86 | GRM5 (0.41) | GRM5SCN2ASCN10AKMT2ANPC1 | |
| SCHEMBL10365988 | 0.82 | GRM5 (0.39) | GRM5SCN2ASCN10AKMT2AALDH1A1 | |
| SCHEMBL10373407 | 0.81 | GRM5 (0.38) | GRM5SCN2ASCN10AKMT2AALDH1A1 | |
| SCHEMBL10707359 | 0.80 | GRM5 (0.37) | GRM5ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10366034 | 0.79 | NPC1 (0.44) | GRM5GSK3BSCN2ASCN10ANPC1 | |
| SCHEMBL10366009 | 0.79 | GRM5 (0.51) | GRM5SCN2ASCN10AKMT2AALDH1A1 | |
| SCHEMBL10366486 | 0.78 | CDK2 (0.45) | GRM5GSK3BDYRK1ASCN2ASCN10A | |
| SCHEMBL10366359 | 0.77 | GRM5 (0.35) | GRM5SCN2ASCN10AALDH1A1NPC1 | |
| SCHEMBL10627087 | 0.77 | GRM5 (0.45) | GRM5SCN2ASCN10AKMT2AALDH1A1 | |
| SCHEMBL10368417 | 0.76 | BRAF (0.45) | GRM5GSK3BSCN2ASCN10AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0227026-B1 | PYRAZINE DERIVATIVE, A PROCESS FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION THEREFROM | Hokuriku Pharmaceutical Co.,Ltd (JP) | 1990-04-18 | — | — | EP | claimed |
| EP-0227026-A1 | Pyrazine derivative, a process for preparation thereof and pharmaceutical composition therefrom | Hokuriku Pharmaceutical Co.,Ltd (JP) | 1987-07-01 | — | — | EP | claimed |
| US-4792547-A | Pyrazine-2-carboxamide derivatives useful in treating allergic disease | HOKURIKU PHARMACEUTICAL CO., LTD. (JP) | 1988-12-20 | — | — | US | disclosed |
| EP-0227026-A1 | Pyrazine derivative, a process for preparation thereof and pharmaceutical composition therefrom | Hokuriku Pharmaceutical Co.,Ltd (JP) | 1987-07-01 | — | — | EP | disclosed |