Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.51 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | CTSA | P10619 | 1/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 5/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 5/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 3/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10366133 | 0.82 | GRM5 (0.41) | GRM5CTSASCN2ASCN10AKDM4E | |
| SCHEMBL10366359 | 0.81 | GRM5 (0.35) | GRM5SCN2ASCN10AMCL1KDM4E | |
| SCHEMBL10935620 | 0.79 | IRAK4 (0.42) | GRM5CTSAKDM4EALDH1A1NPSR1 | |
| SCHEMBL10625332 | 0.79 | NPC1 (0.50) | MCL1KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL10366750 | 0.79 | GRM5 (0.39) | GRM5SCN2ASCN10AMEN1KMT2A | |
| SCHEMBL6440036 | 0.79 | SCN2A (0.37) | SCN2ASCN10AKDM4EMEN1KMT2A | |
| SCHEMBL10365988 | 0.79 | GRM5 (0.39) | GRM5SCN2ASCN10AKDM4EMEN1 | |
| SCHEMBL10368088 | 0.78 | POLB (0.34) | GRM5SCN2ASCN10AKDM4EMEN1 | |
| SCHEMBL10366197 | 0.78 | SCN2A (0.36) | SCN2ASCN10AKDM4EMEN1KMT2A | |
| SCHEMBL10366371 | 0.78 | HSD11B1 (0.37) | SCN2ASCN10AMEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0227026-B1 | PYRAZINE DERIVATIVE, A PROCESS FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION THEREFROM | Hokuriku Pharmaceutical Co.,Ltd (JP) | 1990-04-18 | — | — | EP | disclosed |
| US-4792547-A | Pyrazine-2-carboxamide derivatives useful in treating allergic disease | HOKURIKU PHARMACEUTICAL CO., LTD. (JP) | 1988-12-20 | — | — | US | disclosed |
| US-4738755-A | USING BENZOATES | BERG LLOYD (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0227026-A1 | Pyrazine derivative, a process for preparation thereof and pharmaceutical composition therefrom | Hokuriku Pharmaceutical Co.,Ltd (JP) | 1987-07-01 | — | — | EP | disclosed |
| US-4585526-A | PROPOXYPROPANOL | BERG LLOYD | 1986-04-29 | — | — | US | disclosed |
| US-4488937-A | WITH SULFOLANE | BERG LLOYD | 1984-12-18 | — | — | US | disclosed |