Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFRSF1A | P19438 | 3/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NCF1 | P14598 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 3/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | NCK1 | P16333 | 1/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10365994 | 0.79 | GABRA1 (0.34) | TNFRSF1AGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL16573997 | 0.79 | PDGFRB (0.46) | ADORA1HPGDBACE1NCK1HDAC2 | |
| SCHEMBL28147641 | 0.78 | HDAC1 (0.40) | TNFRSF1AABL1BACE1GABRA1GABRG2 | |
| SCHEMBL29630926 | 0.77 | CYP2A6 (0.54) | PDGFRBPDGFRAPIK3CDPIP5K1CPIK3CA | |
| SCHEMBL11957099 | 0.74 | HDAC1 (0.39) | TNFRSF1AABL1BACE1GABRA1GABRG2 | |
| SCHEMBL423324 | 0.74 | CYP1A2 (0.59) | HPGDNCF1BACE1NCK1 | |
| SCHEMBL13183567 | 0.73 | CYP1A2 (0.50) | TNFRSF1AABL1HPGDBACE1GABRA1 | |
| SCHEMBL12695592 | 0.72 | BACE1 (0.57) | ADORA1HPGDBACE1PDGFRBPDGFRA | |
| SCHEMBL13183630 | 0.72 | CYP2A6 (0.52) | TNFRSF1AABL1HPGDBACE1NCK1 | |
| SCHEMBL15344999 | 0.71 | HPGD (0.46) | ADORA1ABL1HPGDPDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0190857-B1 | QUINOLONE INOTROPIC AGENTS | Pfizer Limited (GB) | 1990-03-21 | — | — | EP | disclosed |
| US-4728654-A | CONGESTIVE HEART FAILURE | PFIZER INC. (US) | 1988-03-01 | — | — | US | disclosed |
| EP-0190857-A2 | Quinolone inotropic agents | Pfizer Limited (GB) | 1986-08-13 | — | — | EP | disclosed |