SCHEMBL10367113

SCHEMBL10367113

CCOC(=O)Nc1ccc2c(c1)CCC(=O)N2

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 1/20 0.57
HDAC4 P56524 1/20 0.57
HDAC1 Q13547 1/20 0.57
HDAC2 Q92769 1/20 0.57
HDAC8 Q9BY41 1/20 0.57
HDAC6 Q9UBN7 1/20 0.57
HDAC9 Q9UKV0 1/20 0.57
CRBN Q96SW2 1/20 0.56
KIF11 P52732 4/20 0.53
MAP4K1 Q92918 1/20 0.50
KMT2A Q03164 4/20 0.49
MEN1 O00255 3/20 0.49
LMNA P02545 2/20 0.49
TSHR P16473 2/20 0.49
ALDH1A1 P00352 1/20 0.49
GAA P10253 1/20 0.49
MAPT P10636 1/20 0.49
ALOX15 P16050 1/20 0.49
HSD17B10 Q99714 1/20 0.49
TDP1 Q9NUW8 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10365651 0.87 CRBN (0.64) HDAC3HDAC4HDAC1HDAC2HDAC8
SCHEMBL6364379 0.84 KMT2A (0.46) HDAC3HDAC4HDAC1HDAC2HDAC8
SCHEMBL9557089 0.79 KMT2A (0.77) KMT2AMEN1LMNATSHRALDH1A1
SCHEMBL10366740 0.78 HDAC3 (0.61) HDAC3HDAC4HDAC1HDAC2HDAC8
SCHEMBL10366850 0.77 HDAC3 (0.57) HDAC3HDAC4HDAC1HDAC2HDAC8
SCHEMBL2000310 0.77 BAZ2B (0.55) KMT2AMEN1LMNATSHRALDH1A1
SCHEMBL7294192 0.77 CRBN (0.56) HDAC3HDAC4HDAC1HDAC2HDAC8
SCHEMBL4578823 0.76 SMYD3 (0.54) HDAC3HDAC4HDAC1HDAC2HDAC8
SCHEMBL20291249 0.76 HDAC3 (0.53) HDAC3HDAC4HDAC1HDAC2HDAC8
SCHEMBL14815939 0.76 MAOA (0.55) ALDH1A1GAAHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0145010-B1 CARBOSTYRIL DERIVATIVES OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1990-03-14 EP claimed
US-4593035-A FOR TREATING HEART DISEASE OTSUKA PHARMACEUTICAL COMPANY LIMITED (JP) 1986-06-03 US claimed
EP-0145010-B1 CARBOSTYRIL DERIVATIVES OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1990-03-14 EP disclosed
US-4593035-A FOR TREATING HEART DISEASE OTSUKA PHARMACEUTICAL COMPANY LIMITED (JP) 1986-06-03 US disclosed
EP-0145010-A2 Carbostyril derivatives OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1985-06-19 EP disclosed