Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 6/20 | 0.45 |
| ▸ | TSHR | P16473 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TNF | P01375 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10369777 | 0.84 | NPC1 (0.46) | RAB9AKMT2AALDH1A1MEN1NPC1 | |
| SCHEMBL11382208 | 0.73 | SMN1; SMN2 (0.62) | MAPTSMN1; SMN2LMNAMAPK1POLB | |
| SCHEMBL5481067 | 0.70 | FSCN1 (0.49) | RAB9AKMT2AALDH1A1HTTNPC1 | |
| SCHEMBL10366568 | 0.70 | TNF (0.36) | RAB9AKMT2AALDH1A1MEN1MAPT | |
| SCHEMBL10369728 | 0.69 | MAPT (0.45) | RAB9AKMT2AALDH1A1MEN1MAPT | |
| SCHEMBL11385374 | 0.68 | PDE1A (0.56) | SMN1; SMN2LMNA | |
| SCHEMBL10367280 | 0.68 | MAPT (0.52) | RAB9AKMT2AALDH1A1MEN1MAPT | |
| SCHEMBL11380345 | 0.67 | MAPK1 (0.61) | MAPTSMN1; SMN2LMNACYP1A2TNF | |
| SCHEMBL3175013 | 0.66 | FSCN1 (0.51) | RAB9AKMT2AALDH1A1MEN1MAPT | |
| SCHEMBL11385104 | 0.66 | MAPK1 (0.60) | KMT2AMEN1MAPTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148883-B1 | ALLOPURINOL PRODRUGS | A/S GEA Farmaceutisk Fabrik (DK) | 1990-02-14 | — | — | EP | disclosed |
| US-4694006-A | Acyl- or acyloxymethyl-allopurinol prodrugs | A/S GEA (DK) | 1987-09-15 | — | — | US | disclosed |