Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 8/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10369240 | 0.87 | NPC1 (0.31) | LMNARAB9ANPC1TP53HDAC6 | |
| SCHEMBL10369567 | 0.85 | ADORA2B (0.34) | LMNARAB9ANPC1TP53MEN1 | |
| SCHEMBL10366971 | 0.79 | KMT2A (0.32) | KMT2ACYP1A2CYP2D6SMN1; SMN2 | |
| SCHEMBL10367385 | 0.70 | RAB9A (0.46) | TNFLMNARAB9ANPC1TP53 | |
| SCHEMBL11382208 | 0.64 | SMN1; SMN2 (0.62) | LMNAMAPTSMN1; SMN2 | |
| SCHEMBL6277232 | 0.60 | DUT (0.49) | LMNAALDH1A1 | |
| SCHEMBL5479694 | 0.59 | LMNA (0.67) | TNFLMNAMEN1KMT2ACYP1A2 | |
| SCHEMBL11380345 | 0.58 | MAPK1 (0.61) | TNFLMNAMAPTCYP1A2SMN1; SMN2 | |
| SCHEMBL14340497 | 0.58 | KMT2A (0.51) | TNFLMNAMEN1ALDH1A1MAPT | |
| SCHEMBL20969072 | 0.55 | ALDH1A1 (0.46) | LMNAMEN1ALDH1A1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148883-B1 | ALLOPURINOL PRODRUGS | A/S GEA Farmaceutisk Fabrik (DK) | 1990-02-14 | — | — | EP | disclosed |
| US-4694006-A | Acyl- or acyloxymethyl-allopurinol prodrugs | A/S GEA (DK) | 1987-09-15 | — | — | US | disclosed |
| EP-0148883-A1 | ALLOPURINOL PRODRUGS. | GEA AS (DK) | 1985-07-24 | — | — | EP | disclosed |
| WO-1985000368-A1 | ALLOPURINOL PRODRUGS | A/S GEA (DK) | 1985-01-31 | — | — | WO | disclosed |