Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 13/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10368378 | 0.79 | ACE (0.53) | ACEKMT2APOLBCYP2D6CYP2C9 | |
| SCHEMBL10369717 | 0.78 | ACE (0.47) | ACEKMT2APOLBCYP2D6CYP2C9 | |
| SCHEMBL10395609 | 0.75 | CHRM2 (0.58) | CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL10395608 | 0.75 | CHRM2 (0.58) | CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL10869405 | 0.75 | ACE (0.56) | ACELMNAKMT2APOLBCYP2D6 | |
| SCHEMBL6548967 | 0.74 | ACE (0.59) | ACELMNAKMT2APOLBCYP2D6 | |
| SCHEMBL10396161 | 0.74 | CHRM2 (0.57) | CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL10372193 | 0.73 | ACE (0.44) | ACELMNAKMT2APOLBCYP2D6 | |
| SCHEMBL10369668 | 0.73 | ACE (0.42) | ACELMNAKMT2ACYP2D6 | |
| SCHEMBL10369643 | 0.73 | ACE (0.42) | ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0184861-B1 | DERIVATIVES OF THE 3-MERCAPTO-2-OXO-1-PYRROLIDINACETIC ACID, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PROTER S.p.A. (IT) | 1990-06-06 | — | — | EP | disclosed |