Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 5/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4762996 | 0.96 | CHRM2 (0.42) | CHRM2CHRM1CHRM4CHRM3ALDH1A1 | |
| SCHEMBL7493133 | 0.96 | CHRM2 (0.42) | CHRM2CHRM1CHRM4CHRM3ALDH1A1 | |
| SCHEMBL4339192 | 0.96 | CHRM2 (0.42) | CHRM2CHRM1CHRM4CHRM3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7498477 | 0.94 | ALDH1A1 (0.45) | CHRM2CHRM1CHRM4CHRM3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7499660 | 0.94 | ALDH1A1 (0.45) | CHRM2CHRM1CHRM4CHRM3ALDH1A1 | |
| Bromide SCHEMBL9298859 | 0.94 | CHRM2 (0.41) | CHRM2CHRM1CHRM4CHRM3ALDH1A1 | |
| SCHEMBL10368012 | 0.94 | CHRM2 (0.45) | CHRM2CHRM1CHRM4CHRM3ALDH1A1 | |
| Bromide SCHEMBL2424119 | 0.94 | CHRM2 (0.41) | CHRM2CHRM1CHRM4CHRM3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL2421080 | 0.94 | ALDH1A1 (0.45) | CHRM2CHRM1CHRM4CHRM3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7093326 | 0.94 | ALDH1A1 (0.45) | CHRM2CHRM1CHRM4CHRM3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0398617-A2 | Process for resolving 1-azabicyclo [2.2.1]heptane-3-carboxylates | MERCK SHARP & DOHME LTD. (GB) | 1990-11-22 | — | — | EP | disclosed |
| US-4870081-A | DEMENTIA | BEECHAM GROUP P.L.C. (GB) | 1989-09-26 | — | — | US | disclosed |
| EP-0257741-A2 | Azabicyclic compounds, process and intermediates for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1988-03-02 | — | — | EP | disclosed |