Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 13/20 | 0.64 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.46 |
| ▸ | CCKBR | P32239 | 2/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.46 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.46 |
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10369498 | 0.85 | CYP11B1 (0.68) | CYP19A1CYP11B1CYP11B2NR1I2ADORA3 | |
| SCHEMBL331966 | 0.83 | CYP19A1 (0.90) | CYP19A1CYP11B1CYP11B2NR1I2ADORA3 | |
| SCHEMBL16160172 | 0.79 | CYP19A1 (0.62) | CYP19A1CYP11B1CYP11B2NR1I2ADORA3 | |
| SCHEMBL7156136 | 0.77 | CYP11B1 (0.80) | CYP19A1CYP11B1CYP11B2NR1I2ADORA3 | |
| SCHEMBL10370788 | 0.76 | CYP19A1 (0.38) | CYP19A1TSHRKMT2A | |
| SCHEMBL10508410 | 0.72 | CYP19A1 (0.53) | CYP19A1MEN1CYP3A4TSHRMAPK1 | |
| SCHEMBL7162563 | 0.71 | CYP11B1 (0.69) | CYP19A1CYP11B1CYP11B2NR1I2ADORA3 | |
| SCHEMBL10370339 | 0.70 | CYP19A1 (0.66) | CYP19A1CYP11B1CYP11B2NR1I2ADORA3 | |
| SCHEMBL10370638 | 0.70 | CYP19A1 (1.00) | CYP19A1CYP11B1CYP11B2NR1I2ADORA3 | |
| SCHEMBL10367810 | 0.69 | CYP19A1 (0.61) | CYP19A1CYP11B1CYP11B2NR1I2ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0166556-B1 | DIARYLDIAZOLYLMETHANES | ELI LILLY AND COMPANY (US) | 1990-12-05 | — | — | EP | disclosed |
| US-4735960-A | TREATING ESTROGEN-DEPENDENT DISEASES | ELI LILLY AND COMPANY (US) | 1988-04-05 | — | — | US | disclosed |
| US-4602025-A | TREATMENT OF ESTROGEN DEPENDENT DISEASES | ELI LILLY AND COMPANY (US) | 1986-07-22 | — | — | US | disclosed |
| EP-0166556-A1 | Diaryldiazolylmethanes | ELI LILLY AND COMPANY (US) | 1986-01-02 | — | — | EP | disclosed |