SCHEMBL331966

SCHEMBL331966

Clc1ccc(C(c2ccc(Cl)cc2)(c2ccc(Cl)cc2)n2ccnc2)cc1

nearest known ligand 0.90

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 14/20 0.90
CYP11B1 P15538 2/20 0.67
CYP11B2 P19099 2/20 0.67
NR1I2 O75469 2/20 0.57
ADORA3 P0DMS8 2/20 0.57
TBXA2R P21731 2/20 0.57
CCKBR P32239 2/20 0.57
OPRK1 P41145 2/20 0.57
SLC6A3 Q01959 2/20 0.57
KCNH2 Q12809 2/20 0.57
NR1H4 Q96RI1 2/20 0.57
MEN1 O00255 1/20 0.57
SLC22A1 O15245 1/20 0.57
KCNN4 O15554 1/20 0.57
GMNN O75496 1/20 0.57
USP2 O75604 1/20 0.57
TRPM2 O94759 1/20 0.57
ABCB11 O95342 1/20 0.57
EGFR P00533 1/20 0.57
CA2 P00918 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7156136 0.93 CYP11B1 (0.80) CYP19A1CYP11B1CYP11B2NR1I2ADORA3
SCHEMBL7162563 0.86 CYP11B1 (0.69) CYP19A1CYP11B1CYP11B2NR1I2ADORA3
SCHEMBL10370638 0.85 CYP19A1 (1.00) CYP19A1CYP11B1CYP11B2NR1I2ADORA3
SCHEMBL10368231 0.83 CYP19A1 (0.64) CYP19A1CYP11B1CYP11B2NR1I2ADORA3
SCHEMBL5591937 0.83 CYP19A1 (0.63) CYP19A1CYP11B1CYP11B2CYP2A6CYP2B6
SCHEMBL5591889 0.83 CYP19A1 (0.63) CYP19A1CYP11B1CYP11B2CYP2A6CYP2B6
SCHEMBL10370339 0.82 CYP19A1 (0.66) CYP19A1CYP11B1CYP11B2NR1I2ADORA3
SCHEMBL16160172 0.82 CYP19A1 (0.62) CYP19A1CYP11B1CYP11B2NR1I2ADORA3
SCHEMBL10367791 0.81 CYP19A1 (0.62) CYP19A1CYP11B1CYP11B2NR1I2ADORA3
SCHEMBL10367810 0.81 CYP19A1 (0.61) CYP19A1CYP11B1CYP11B2NR1I2ADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 118 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210128584-A1 USE OF GLUCOCORTICOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS CORCEPT THERAPEUTICS INCORPORATED 2021-05-06 US claimed
EP-3607942-A1 MEDICAMENT AND METHOD OF DIAGNOSIS University of Sheffield (GB) 2020-02-12 EP claimed
US-20160067264-A1 MEDICAMENT AND METHOD OF DIAGNOSIS UNIVERSITY OF SHEFFIELD (GB) 2016-03-10 US claimed
US-20140170768-A1 METHOD FOR MONITORING AND ASSESSING PITUITARY FUNCTION I-CALQ LLC 2014-06-19 US claimed
EP-2532350-A1 Pharmaceutical combination of a glucocorticoid receptor antagonist and a cortisol synthesis inhibitor for treating cushing's syndrome Laboratoire HRA Pharma (FR) 2012-12-12 EP claimed
US-20110224179-A1 MEDICAMENT AND METHOD OF DIAGNOSIS UNIVERSITY OF SHEFFIELD (GB) 2011-09-15 US claimed
EP-2364146-A1 MEDICAMENT AND METHOD OF DIAGNOSIS The University Of Sheffield (GB) 2011-09-14 EP claimed
US-20110166115-A1 USE OF MIFEPRISTONE FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS CORCEPT THERAPEUTICS, INC. (US) 2011-07-07 US claimed
EP-2306830-A1 USE OF MIFEPRISTONE FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS Corcept Therapeutics, Inc. (US) 2011-04-13 EP claimed
US-20100261693-A1 METHOD FOR TREATING CUSHING'S SYNDROME LABORATOIRE HRA PHARMA (FR) 2010-10-14 US claimed
WO-2010002901-A1 USE OF MIFEPRISTONE FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS CORCEPT THERAPEUTICS, INC. (US) 2010-01-07 WO claimed
WO-2009050136-A2 GLUCOCORTICOID RECEPTOR ANTAGONISTS SUCH AS MIFEPRISTONE FOR TREATING CUSHING' S SYNDROME LABORATOIRE HRA PHARMA (FR) 2009-04-23 WO claimed
EP-2012796-A2 THE USE OF A GLUCOCORTICOID RECEPTOR II ANTAGONIST TO TREAT DEPRESSION IN PATIENTS TAKING IL-2 Corcept Therapeutics, Inc. (US) 2009-01-14 EP claimed
WO-2007131041-A2 THE USE OF A GLUCOCORTICOID RECEPTOR II ANTAGONIST TO TREAT DEPRESSION IN PATIENTS TAKING IL-2 CORCEPT THERAPEUTICS, INC. (US) 2007-11-15 WO claimed
US-20020065259-A1 Glucocorticoid blocking agents for increasing blood-brain barrier permeability BIOPHARMA SECURED DEBT FUND II SUB, S.AR.L (LU) 2002-05-30 US claimed
WO-2002040018-A1 TREATMENT OF GLAUCOMA AND OCULAR HYPERTENSION ALCON, INC. (CH) 2002-05-23 WO claimed
WO-2002017930-A2 GLUCOCORTICOID BLOCKING AGENTS FOR INCREASING BLOOD-BRAIN BARRIER PERMEABILITY THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2002-03-07 WO claimed
EP-1047410-A1 TREATMENT OF GLC1A GLAUCOMA WITH NON-STEROIDAL GLUCOCORTICOID ANTAGONISTS ALCON LABORATORIES, INC. (US) 2000-11-02 EP claimed
US-6051573-A Treatment of GLC1A glaucoma with non-steroidal glucocorticoid antagonists ALCON LABORATORIES, INC. (US) 2000-04-18 US claimed
WO-1999032101-A1 TREATMENT OF GLC1A GLAUCOMA WITH NON-STEROIDAL GLUCOCORTICOID ANTAGONISTS ALCON LABORATORIES, INC. (US) 1999-07-01 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100261693-A1 METHOD FOR TREATING CUSHING'S SYNDROME MC2R, CRH, CRHR2 CYP19A1 289/4885CYP11B1 54/4885CYP11B2 40/4885
US-20110166115-A1 USE OF MIFEPRISTONE FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS CRHR1, NR3C1, CRH CYP19A1 1166/4885CYP11B1 381/4885CYP11B2 432/4885
US-20110224179-A1 MEDICAMENT AND METHOD OF DIAGNOSIS CRH, SHBG, MC2R CYP19A1 166/4885CYP11B1 20/4885CYP11B2 17/4885
US-20160067264-A1 MEDICAMENT AND METHOD OF DIAGNOSIS CRH, SHBG, MC2R CYP19A1 118/4885CYP11B1 19/4885CYP11B2 18/4885
US-20210128584-A1 USE OF GLUCOCORTICOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS NR3C1, CRHR1, NR3C2 CYP19A1 3119/4885CYP11B1 324/4885CYP11B2 288/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.