Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 3/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA9 | Q16790 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8757032 | 1.00 | SMN1; SMN2 (0.53) | SMN1; SMN2KMT2AALDH1A1GFERCA12 | |
| SCHEMBL22029512 | 1.00 | SMN1; SMN2 (0.53) | SMN1; SMN2KMT2AALDH1A1GFERCA12 | |
| SCHEMBL8757039 | 1.00 | SMN1; SMN2 (0.53) | SMN1; SMN2KMT2AALDH1A1GFERCA12 | |
| SCHEMBL10367497 | 1.00 | SMN1; SMN2 (0.53) | SMN1; SMN2KMT2AALDH1A1GFERCA12 | |
| SCHEMBL14383569 | 0.81 | ALDH1A1 (0.44) | SMN1; SMN2KMT2AALDH1A1CA12CA2 | |
| SCHEMBL610345 | 0.81 | TP53 (0.41) | KMT2AALDH1A1CA12CA2CA9 | |
| SCHEMBL8755989 | 0.80 | ALDH1A1 (0.73) | KMT2AALDH1A1CA12CA2CA9 | |
| SCHEMBL8756569 | 0.80 | ALDH1A1 (0.73) | KMT2AALDH1A1CA12CA2CA9 | |
| SCHEMBL8755991 | 0.80 | ALDH1A1 (0.73) | KMT2AALDH1A1CA12CA2CA9 | |
| SCHEMBL8756493 | 0.80 | ALDH1A1 (0.73) | KMT2AALDH1A1CA12CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0150073-B1 | 3,4-DISUBSTITUTED-1,2,5-OXADIAZOLES HAVING HISTAMINE H2-RECEPTOR ANTAGONIST ACTIVITY | Bristol-Myers Squibb Company (US) | 1990-09-26 | — | — | EP | disclosed |
| EP-0150073-A1 | 3,4-Disubstituted-1,2,5-oxadiazoles having histamine H2-receptor antagonist activity | Bristol-Myers Squibb Company (US) | 1985-07-31 | — | — | EP | disclosed |
| US-4507485-A | 3,4-Disubstituted-1,2,5-oxadiazoles having histamine H2 -receptor antagonist activity | BRISTOL-MYERS COMPANY (US) | 1985-03-26 | — | — | US | disclosed |