Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EEF2K | O00418 | 1/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.50 |
| ▸ | PDE4A | P27815 | 4/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.41 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6641641 | 0.75 | EEF2K (0.54) | EEF2KADORA2AADORA2BPDE4APDE4B | |
| SCHEMBL10373098 | 0.75 | KMT2A (0.52) | ADORA2AADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL17434387 | 0.74 | EEF2K (0.52) | EEF2KADORA2AADORA2BPDE4APDE4B | |
| SCHEMBL10370620 | 0.74 | PDE1A (0.54) | ADORA2AADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL17434159 | 0.73 | ADORA2A (0.49) | EEF2KADORA2AADORA2BPDE4APDE4B | |
| SCHEMBL2632960 | 0.71 | CDK4 (0.62) | — | |
| SCHEMBL2738169 | 0.71 | FGFR1 (0.40) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL14301174 | 0.71 | BTK (0.46) | KDM4EALDH1A1HPGDMAPK1HSD17B10 | |
| SCHEMBL24765254 | 0.70 | ADORA2A (0.48) | ADORA2AADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL9040396 | 0.70 | ADORA2A (0.49) | EEF2KADORA2AADORA2BPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0163599-B1 | PYRIMIDOPYRIMIDINE DERIVATIVES, PROCESSES FOR PRODUCING THEM, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANTI-ALLERGIC AGENTS | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1990-03-21 | — | — | EP | disclosed |
| US-4886807-A | TREATMENT OF BRONCHIAL ASTHMA, URTICARIA, ALLERGIC RHINITIS, ALLERGIC DERMATOSES OR ALLERGIC CONJUCTIVITIS | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1989-12-12 | — | — | US | disclosed |
| EP-0163599-A2 | Pyrimidopyrimidine derivatives, processes for producing them, pharmaceutical compositions containing them and their use as anti-allergic agents | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1985-12-04 | — | — | EP | disclosed |