Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 9/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.36 |
| ▸ | RET | P07949 | 2/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.36 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.36 |
| ▸ | STK10 | O94804 | 1/20 | 0.36 |
| ▸ | LATS1 | O95835 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | YES1 | P07947 | 1/20 | 0.36 |
| ▸ | LYN | P07948 | 1/20 | 0.36 |
| ▸ | HCK | P08631 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10293630 | 0.91 | MAP2K1 (0.40) | ROCK2CYP3A4MAP2K1RETCDC7 | |
| SCHEMBL10325117 | 0.91 | MAP2K1 (0.40) | ROCK2CYP3A4MAP2K1RETCDC7 | |
| SCHEMBL26907228 | 0.89 | MAP2K1 (0.48) | ROCK2CYP3A4MAP2K1RETCDC7 | |
| SCHEMBL10326049 | 0.89 | MAP2K1 (0.48) | ROCK2CYP3A4MAP2K1RETCDC7 | |
| SCHEMBL4081822 | 0.89 | MAP2K1 (0.48) | ROCK2CYP3A4MAP2K1RETCDC7 | |
| SCHEMBL10364455 | 0.89 | MAP2K1 (0.38) | ROCK2CYP3A4MAP2K1RETCDC7 | |
| SCHEMBL10324778 | 0.89 | MAP2K1 (0.38) | ROCK2CYP3A4MAP2K1RETCDC7 | |
| SCHEMBL10325557 | 0.88 | MAP2K1 (0.40) | ROCK2CYP3A4MAP2K1RETCDC7 | |
| SCHEMBL12237872 | 0.88 | MAP2K1 (0.40) | ROCK2CYP3A4MAP2K1RETCDC7 | |
| SCHEMBL15427656 | 0.88 | MAP2K1 (0.40) | ROCK2CYP3A4MAP2K1RETCDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012095505-A1 | ANTICANCER THERAPY WITH DUAL AURORA KINASE / MEK INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-07-19 | — | — | WO | disclosed |