Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 8/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.47 |
| ▸ | CYP2E1 | P05181 | 7/20 | 0.47 |
| ▸ | CYP2C8 | P10632 | 7/20 | 0.47 |
| ▸ | CYP2B6 | P20813 | 7/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | ATP1A1 | P05023 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10370822 | 0.94 | BRS3 (0.51) | BRS3CYP2D6CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL10372557 | 0.93 | ATP4A (0.49) | BRS3CYP2D6CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL10371409 | 0.91 | CYP2D6 (0.51) | BRS3CYP2D6CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL10371942 | 0.90 | BRS3 (0.49) | BRS3CYP2D6CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL6457331 | 0.90 | BRS3 (0.57) | BRS3CYP2D6CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL10373587 | 0.88 | BRS3 (0.50) | BRS3CYP2D6CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL10370611 | 0.87 | ATP4A (0.49) | BRS3CYP2D6CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL10371882 | 0.87 | CYP2D6 (0.49) | BRS3CYP2D6CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL10370946 | 0.86 | CYP2E1 (0.49) | CYP2D6CYP2C9CYP2C19CYP3A4CYP2E1 | |
| SCHEMBL10371431 | 0.85 | CYP2D6 (0.52) | BRS3CYP2D6CYP2C9CYP2C19CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0390842-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1990-10-10 | — | — | EP | disclosed |
| WO-1989005299-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1989-06-15 | — | — | WO | disclosed |