Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31673199 | 0.84 | KDM4E (0.54) | SMN1; SMN2TSHRALDH1A1LMNAPOLB | |
| SCHEMBL31673273 | 0.84 | KDM4E (0.55) | SMN1; SMN2TSHRALDH1A1LMNAPOLB | |
| SCHEMBL31673288 | 0.84 | KDM4E (0.50) | SMN1; SMN2TSHRALDH1A1LMNAPOLB | |
| SCHEMBL4508479 | 0.83 | DHODH (0.50) | SMN1; SMN2TSHRALDH1A1LMNAPOLB | |
| SCHEMBL4508469 | 0.83 | DHODH (0.50) | SMN1; SMN2TSHRALDH1A1LMNAPOLB | |
| SCHEMBL4508476 | 0.83 | DHODH (0.50) | SMN1; SMN2TSHRALDH1A1LMNAPOLB | |
| SCHEMBL24846167 | 0.82 | MAPT (0.44) | SMN1; SMN2TSHRALDH1A1LMNAPOLB | |
| SCHEMBL24845865 | 0.81 | CYP1A2 (0.47) | SMN1; SMN2TSHRALDH1A1LMNAPOLB | |
| SCHEMBL24843063 | 0.81 | TSHR (0.43) | SMN1; SMN2TSHRALDH1A1LMNAPOLB | |
| SCHEMBL24846097 | 0.81 | ALDH1A1 (0.45) | SMN1; SMN2TSHRALDH1A1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0187487-B1 | BENZOTHIOPHENES AND BENZOFURANS HAVING ANTIALLERGIC ACTIVITY | WARNER-LAMBERT COMPANY (US) | 1990-08-29 | — | — | EP | disclosed |
| US-4703053-A | Benzothiophenes and benzofurans and antiallergic use thereof | WARNER-LAMBERT COMPANY (US) | 1987-10-27 | — | — | US | disclosed |
| EP-0187487-A1 | Benzothiophenes and benzofurans having antiallergic activity | WARNER-LAMBERT COMPANY (US) | 1986-07-16 | — | — | EP | disclosed |