Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HNF4A | P41235 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
| ▸ | FABP3 | P05413 | 1/20 | 0.44 |
| ▸ | FABP4 | P15090 | 1/20 | 0.44 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18705315 | 0.85 | PTPN1 (0.47) | HNF4ANR1H4FABP3FABP4FABP5 | |
| SCHEMBL5156328 | 0.82 | HNF4A (0.53) | HNF4ANR1H4FABP3FABP4FABP5 | |
| SCHEMBL11340527 | 0.80 | HNF4A (0.54) | HNF4ANR1H4FABP3FABP4FABP5 | |
| SCHEMBL30394743 | 0.80 | HNF4A (0.58) | HNF4ANR1H4FABP3FABP4FABP5 | |
| SCHEMBL4632581 | 0.80 | HNF4A (0.58) | HNF4ANR1H4FABP3FABP4FABP5 | |
| SCHEMBL5149360 | 0.79 | HNF4A (0.50) | HNF4ANR1H4FABP3FABP4FABP5 | |
| SCHEMBL10375122 | 0.79 | HTT (0.47) | FABP3FABP4FABP5ALDH1A1KDM4E | |
| SCHEMBL17799595 | 0.79 | HNF4A (0.56) | HNF4ANR1H4FABP3FABP4FABP5 | |
| SCHEMBL11511175 | 0.78 | PTPN11 (0.54) | HNF4AKDM4EKMT2AMEN1L3MBTL1 | |
| SCHEMBL8797209 | 0.78 | PTGER1 (0.55) | HNF4AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0187487-B1 | BENZOTHIOPHENES AND BENZOFURANS HAVING ANTIALLERGIC ACTIVITY | WARNER-LAMBERT COMPANY (US) | 1990-08-29 | — | — | EP | disclosed |
| US-4703053-A | Benzothiophenes and benzofurans and antiallergic use thereof | WARNER-LAMBERT COMPANY (US) | 1987-10-27 | — | — | US | disclosed |
| EP-0187487-A1 | Benzothiophenes and benzofurans having antiallergic activity | WARNER-LAMBERT COMPANY (US) | 1986-07-16 | — | — | EP | disclosed |