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Sugi Predict / Targets / HNF4A

HNF4A

Hepatocyte nuclear factor 4-alpha · P41235 · HNF4A on Sugi Atlas →

19,301 patent compounds predicted against HNF4A, 12,497 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL727284 SCHEMBL727284 0.51 6/20
SCHEMBL727908 SCHEMBL727908 0.44 6/20
SCHEMBL728016 SCHEMBL728016 0.43 6/20
SCHEMBL728017 SCHEMBL728017 0.43 6/20
SCHEMBL727909 SCHEMBL727909 0.42 6/20
SCHEMBL847484 SCHEMBL847484 0.62 5/20
SCHEMBL489842 SCHEMBL489842 0.56 4/20
Mesalamine Mesalamine (SCHEMBL140264) 0.55 4/20
SCHEMBL658651 SCHEMBL658651 0.51 4/20
SCHEMBL130491 SCHEMBL130491 0.50 4/20
Salicylic Acid Salicylic Acid (SCHEMBL290828) 0.48 4/20
Salicylic Acid Salicylic Acid (SCHEMBL15847) 0.42 4/20
Biphenyl Biphenyl (SCHEMBL461631) 0.67 3/20
SCHEMBL505412 SCHEMBL505412 0.64 3/20
SCHEMBL901069 SCHEMBL901069 0.61 3/20
SCHEMBL623796 SCHEMBL623796 0.60 3/20
SCHEMBL667582 SCHEMBL667582 0.57 3/20
SCHEMBL332581 SCHEMBL332581 0.54 3/20
SCHEMBL343127 SCHEMBL343127 0.53 3/20
SCHEMBL699045 SCHEMBL699045 0.53 3/20

Clinical trials — most relevant to HNF4A by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Switching From Insulin to Sulfonylurea in Diabetes Associated With Variants in MODY Genes PHASE4UNKNOWN
Safety Study of Pioglitazone Compared To Glyburide on Liver Function PHASE4COMPLETED
Role of Pioglitazone in the Treatment of Non-alcoholic Steatohepatitis (NASH) PHASE4COMPLETED
Pioglitazone Study of Triglyceride Changes in Subjects With Type 2 Diabetes After Conversion From Rosiglitazone. PHASE4COMPLETED
Effect Of Exenatide Treatment on Liver Fat Content in Patients With Diabetes PHASE4COMPLETED
Effect of Silymarin in Rheumatoid Arthritis Patients Treated With Methotrexate PHASE4NOT_YET_RECRUITING
Efficacy and Safety of Pioglitazone and Metformin Combination Therapy in Treating Type 2 Diabetes Mellitus. PHASE3COMPLETED
Efficacy Study of Pioglitazone Compared to Glimepiride on Coronary Atherosclerotic Disease Progression in Subjects With Type 2 Diabetes Mellitus PHASE3COMPLETED
Effects of Pioglitazone on High-density Lipoprotein (HDL) Function in Persons With Diabetes PHASE3COMPLETED
Efficacy of Alogliptin and Pioglitazone in Subjects With Type 2 Diabetes Mellitus PHASE3COMPLETED
A Study of Bezafibrate in Mitochondrial Myopathy PHASE2COMPLETED
Fibrates in Pediatric Cholestasis PHASE2COMPLETED
A Clinical Trial Evaluating the Safety and Efficacy of Intravenous CD-801 in Treating Advanced HCC Patients EARLY_PHASE1RECRUITING
A Clinical Trial for the Safety and Efficacy of CD-801 in Patients With Advanced Hepatocellular Carcinoma EARLY_PHASE1COMPLETED
Pharmacogenetic Profiling of Antipsychotics-Induced X-Syndrome and Diabetes (PAXD) nanUNKNOWN
Micro RNA Levels in NAFLD nanUNKNOWN
Application of UCPCR as a Testing Tool for Identification of MODY Patients in the UAE nanUNKNOWN
Identifying Maturity-onset Diabetes of the Young in Emirati Patients nanNOT_YET_RECRUITING
Using Pharmacogenetics to Improve Treatment in Early-onset Diabetes nanCOMPLETED
Impact of SGLT2 on Glucosuria in HNF1A-MODY nanCOMPLETED
Observational Study to Assess Glycosylated Hemoglobin Changes After 6 Months of Treatment With Pioglitazone. nanCOMPLETED
Effect of SGLT2 Inhibitors on NAFLD in Type 2 Diabetic Patients with Diabetic Nephropathy nanNOT_YET_RECRUITING
Genomic Study of Young-Onset Diabetes Mellitus nanUNKNOWN
EXtremely Early-onset Type 1 Diabetes EXtremely Early-onset Type 1 Diabetes (A Musketeers' Memorandum Study) nanRECRUITING
Role of Obeticholic Acid in the Patients of NAFLD With Raised ALT nanCOMPLETED
Molecular Mechanisms of Exercise Benefits to Insulin Resistant People nanCOMPLETED
Predisposition Genes in Monogenic Diabetes (DIAMONO) nanCOMPLETED
Mechanisms of Glucose Lowering Effect of Colesevelam HCl nanCOMPLETED
Omics-based Predictors of NAFLD/Potential NASH nanUNKNOWN
Role of the Liver in Glucose Homeostasis Using Metabolic Imaging nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a HNF4A binder may also engage these)

ProteinNameSimilarity
P22449 — 1.000 P22449 →
P49698 — 1.000 P49698 →
Q91766 — 1.000 Q91766 →
P28700 — 1.000 P28700 →
P79926 — 1.000 P79926 →
P51129 — 0.999 P51129 →
O45436 — 0.999 O45436 →
Q14541 — 0.999 Q14541 →
P31396 — 0.998 P31396 →
Q9XTJ4 — 0.998 Q9XTJ4 →
Q9XYB7 — 0.998 Q9XYB7 →
RXRA Retinoic acid receptor RXR-alpha 0.998 landscape →
Q90416 — 0.998 Q90416 →
O76202 — 0.998 O76202 →
P51128 — 0.997 P51128 →
Q9WUU6 — 0.997 Q9WUU6 →
Q17771 — 0.997 Q17771 →
Q0VC20 — 0.997 Q0VC20 →
Q7SYN5 — 0.996 Q7SYN5 →
P45448 — 0.996 P45448 →
Q8HYL6 — 0.996 Q8HYL6 →
Q21878 — 0.996 Q21878 →
P54779 — 0.996 P54779 →
ESRRB Steroid hormone receptor ERR2 0.996 landscape →
Q18192 — 0.996 Q18192 →
Q5BJR8 — 0.996 Q5BJR8 →
Q05343 — 0.996 Q05343 →
P49882 — 0.996 P49882 →
P28701 — 0.996 P28701 →
Q9QWM1 — 0.995 Q9QWM1 →