Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RUNX1 | Q01196 | 2/20 | 0.37 |
| ▸ | AMY1A | P0DUB6 | 10/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10374056 | 0.90 | PDE2A (0.38) | RUNX1AMY1APDE2AKDM4ECYP1A2 | |
| SCHEMBL10374204 | 0.90 | AMY1A (0.36) | RUNX1AMY1APDE2AKDM4ECYP1A2 | |
| SCHEMBL10374135 | 0.88 | PDE2A (0.37) | RUNX1AMY1APDE2AKDM4ECYP1A2 | |
| SCHEMBL10373614 | 0.81 | KDM4E (0.41) | AMY1AKDM4EPDE5APDE3BPDE3A | |
| SCHEMBL10374338 | 0.81 | PDE3A (0.45) | RUNX1AMY1APDE2AKDM4ECYP1A2 | |
| SCHEMBL10374316 | 0.81 | CDK4 (0.42) | AMY1APDE5APDE3BPDE3A | |
| Hydrochloric Acid SCHEMBL10374309 | 0.80 | PDE7A (0.42) | AMY1AKDM4EPDE5APDE3BPDE3A | |
| SCHEMBL10374611 | 0.80 | AMY1A (0.36) | AMY1AKDM4EPDE5APDE3BPDE3A | |
| SCHEMBL10373150 | 0.80 | CYP17A1 (0.42) | AMY1AKDM4ECYP1A2CYP3A4 | |
| SCHEMBL10376023 | 0.79 | PDE2A (0.37) | AMY1APDE2AKDM4ECYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0186010-B1 | PYRROLO BENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Roche Diagnostics GmbH (DE) | 1990-01-31 | — | — | EP | disclosed |
| US-4810801-A | Pyrrolobenzimidazoles, pharmaceutical compositions containing them, and use of them to treat certain heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1989-03-07 | — | — | US | disclosed |
| US-4710510-A | Pyrrolobenzimidazoles, pharmaceutical compositions containing them, and use of them to treat certain heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1987-12-01 | — | — | US | disclosed |
| EP-0186010-A1 | Pyrrolo benzimidazoles, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1986-07-02 | — | — | EP | disclosed |