Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.50 |
| ▸ | WDR5 | P61964 | 9/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10867553 | 0.91 | ALDH1A1 (0.53) | ALDH1A1WDR5GAALMNAPOLB | |
| SCHEMBL10867548 | 0.91 | ALDH1A1 (0.53) | ALDH1A1WDR5GAALMNAPOLB | |
| SCHEMBL10375265 | 0.83 | KMT2A (0.46) | ALDH1A1GAALMNAKMT2AHTT | |
| SCHEMBL10375348 | 0.82 | KMT2A (0.43) | ALDH1A1LMNAKMT2AMAPK1CYP2D6 | |
| SCHEMBL10375262 | 0.80 | KMT2A (0.41) | ALDH1A1KMT2A | |
| SCHEMBL10375282 | 0.78 | ALDH1A1 (0.55) | ALDH1A1GAAPOLBKMT2A | |
| SCHEMBL282589 | 0.76 | ALDH1A1 (0.62) | ALDH1A1WDR5GAALMNAPOLB | |
| SCHEMBL10375516 | 0.74 | KDM4E (0.54) | ALDH1A1GAALMNAKMT2AHTT | |
| SCHEMBL10375206 | 0.73 | PDE4D (0.56) | ALDH1A1LMNAPOLBMAPK1 | |
| SCHEMBL10375294 | 0.73 | KMT2A (0.48) | ALDH1A1GAALMNAKMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0169712-B1 | NEW PYRIMIDINE DERIVATIVES, PROCESSES FOR PREPARATION THEREOF AND COMPOSITION CONTAINING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-12-12 | — | — | EP | disclosed |
| US-4698340-A | TREATMENT OF CEREBROVASCULAR DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-10-06 | — | — | US | disclosed |
| EP-0169712-A2 | New pyrimidine derivatives, processes for preparation thereof and composition containing the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-01-29 | — | — | EP | disclosed |